Literature DB >> 34890433

Correction: SARS-CoV-2 suppresses IFNβ production mediated by NSP1, 5, 6, 15, ORF6 and ORF7b but does not suppress the effects of added interferon.

Maya Shemesh, Turgut E Aktepe, Joshua M Deerain, Julie L McAuley, Michelle D Audsley, Cassandra T David, Damian F J Purcell, Victoria Urin, Rune Hartmann, Gregory W Moseley, Jason M Mackenzie, Gideon Schreiber, Daniel Harari.

Abstract

[This corrects the article DOI: 10.1371/journal.ppat.1009800.].

Entities: Chemical

Year: 2021 PMID： 34890433 PMCID： PMC8664222 DOI： 10.1371/journal.ppat.1010146

Source DB: PubMed Journal: PLoS Pathog ISSN： 1553-7366 Impact factor: 6.823

S4 Fig is a duplicate of S3 Fig. Please view the correct S4 Fig below.

IFNα and IFNγ transcription levels are not altered by MAVS or SARS-CoV-2 genes.

HEK-293T cells were transfected with MAVS and a SARS-CoV-2 viral gene (or control). 24 hours post transfection transcript levels were analyzed by qPCR for expression of IFNα2, IFNα4, IFNα6, IFNα10 and IFNγ. The data presented are expression levels normalized to the housekeeping gene HPRT1 (ΔCT). Data presented are means of 2–4 independent experiments and their standard error. (TIF) Click here for additional data file.

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Review 1. The Evolutionary Dance between Innate Host Antiviral Pathways and SARS-CoV-2.

Authors: Saba R Aliyari; Natalie Quanquin; Olivier Pernet; Shilei Zhang; Lulan Wang; Genhong Cheng
Journal: Pathogens Date: 2022-05-03

2. Roles of antiviral sensing and type I interferon signaling in the restriction of SARS-CoV-2 replication.

Authors: Elizabeth Geerling; Amanda N Pinski; Taylor E Stone; Richard J DiPaolo; Michael Z Zulu; Kevin J Maroney; James D Brien; Ilhem Messaoudi; Amelia K Pinto
Journal: iScience Date: 2021-12-03

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