Literature DB >> 34889611

Novel Δ8-Tetrahydrocannabinol Vaporizers Contain Unlabeled Adulterants, Unintended Byproducts of Chemical Synthesis, and Heavy Metals.

Jiries Meehan-Atrash1, Irfan Rahman1.   

Abstract

Cannabis e-cigarettes containing Δ8-tetrahydrocannabinol (Δ8-THC) produced synthetically from hemp-derived cannabidiol (CBD) have recently risen in popularity as a legal means of cannabis consumption, but questions surrounding purity and unlabeled additives have created doubts of their safety. Herein, NMR, GC-MS, and ICP-MS were used to analyze major components of 27 products from 10 brands, and it was determined none of these had accurate Δ8-THC labeling, 11 had unlabeled cutting agents, and all contained reaction side-products including olivetol, Δ4(8)-iso-tetrahydrocannabinol, 9-ethoxyhexahydrocannabinol, Δ9-tetrahydrocannabinol (Δ9-THC), heavy metals, and a novel previously undescribed cannabinoid, iso-tetrahydrocannabifuran.

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Year:  2021        PMID： 34889611      PMCID： PMC8898185          DOI： 10.1021/acs.chemrestox.1c00388

Source DB:  PubMed          Journal:  Chem Res Toxicol        ISSN： 0893-228X            Impact factor:   3.739


  18 in total

1.  Toxaphene chemistry: separation and characterisation of selected enantiomers of the Polychloropinene mixtures.

Authors:  Alexey Trukhin; Fedor Kruchkov; Lars Kr Hansen; Roland Kallenborn; Anastasia Kiprianova; Vladimir Nikiforov
Journal:  Chemosphere       Date:  2007-01-10       Impact factor: 7.086

2.  Synthetic route sourcing of illicit at home cannabidiol (CBD) isomerization to psychoactive cannabinoids using ion mobility-coupled-LC-MS/MS.

Authors:  Thomas D Kiselak; Rachel Koerber; Guido F Verbeck
Journal:  Forensic Sci Int       Date:  2020-01-30       Impact factor: 2.395

Review 3.  The e-Psychonauts' 'Spiced' World; Assessment of the Synthetic Cannabinoids' Information Available Online.

Authors:  Caroline Zangani; Fabrizio Schifano; Flavia Napoletano; Davide Arillotta; Liam Gilgar; Amira Guirguis; John M Corkery; Orsola Gambini; Alessandro Vento
Journal:  Curr Neuropharmacol       Date:  2020       Impact factor: 7.363

4.  Cannabis, Vaping, and Respiratory Symptoms in a Probability Sample of U.S. Youth.

Authors:  Carol J Boyd; Sean Esteban McCabe; Rebecca J Evans-Polce; Philip T Veliz
Journal:  J Adolesc Health       Date:  2021-03-03       Impact factor: 7.830

5.  Aerosol Gas-Phase Components from Cannabis E-Cigarettes and Dabbing: Mechanistic Insight and Quantitative Risk Analysis.

Authors:  Jiries Meehan-Atrash; Wentai Luo; Kevin J McWhirter; Robert M Strongin
Journal:  ACS Omega       Date:  2019-09-16

Review 6.  Chemical Basis of Reactive Oxygen Species Reactivity and Involvement in Neurodegenerative Diseases.

Authors:  Fabrice Collin
Journal:  Int J Mol Sci       Date:  2019-05-15       Impact factor: 5.923

7.  Analysis of Cannabinoid-Containing Fluids in Illicit Vaping Cartridges Recovered from Pulmonary Injury Patients: Identification of Vitamin E Acetate as a Major Diluent.

Authors:  Bryan Duffy; Lingyun Li; Shijun Lu; Lorie Durocher; Mark Dittmar; Emily Delaney-Baldwin; Deepika Panawennage; David LeMaster; Kristen Navarette; David Spink
Journal:  Toxics       Date:  2020-01-24

8.  Chemical Constituents Involved in E-Cigarette, or Vaping Product Use-Associated Lung Injury (EVALI).

Authors:  Thivanka Muthumalage; Michelle R Friedman; Matthew D McGraw; Garry Ginsberg; Alan E Friedman; Irfan Rahman
Journal:  Toxics       Date:  2020-04-03

9.  Update: Characteristics of a Nationwide Outbreak of E-cigarette, or Vaping, Product Use-Associated Lung Injury - United States, August 2019-January 2020.

Authors:  Vikram P Krishnasamy; Benjamin D Hallowell; Jean Y Ko; Amy Board; Kathleen P Hartnett; Phillip P Salvatore; Melissa Danielson; Aaron Kite-Powell; Evelyn Twentyman; Lindsay Kim; Alissa Cyrus; Megan Wallace; Paul Melstrom; Brittani Haag; Brian A King; Peter Briss; Christopher M Jones; Lori A Pollack; Sascha Ellington
Journal:  MMWR Morb Mortal Wkly Rep       Date:  2020-01-24       Impact factor: 17.586

10.  Cannabidiol as the Substrate in Acid-Catalyzed Intramolecular Cyclization.

Authors:  Paola Marzullo; Francesca Foschi; Davide Andrea Coppini; Fabiola Fanchini; Lucia Magnani; Selina Rusconi; Marcello Luzzani; Daniele Passarella
Journal:  J Nat Prod       Date:  2020-09-29       Impact factor: 4.050
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  3 in total

1.  Cannabinoid Vaping Products Present Novel Challenges for Assessment of Respiratory Health Effects.

Authors:  Charlotte A Love; Kevin D Schichlein; Phillip W Clapp; Ilona Jaspers
Journal:  Toxicol Sci       Date:  2022-06-28       Impact factor: 4.109

2.  Comparison of State-Level Regulations for Cannabis Contaminants and Implications for Public Health.

Authors:  Laura E Jameson; Kendra D Conrow; Dorina V Pinkhasova; Haleigh L Boulanger; Hyunji Ha; Negar Jourabchian; Steven A Johnson; Michael P Simeone; Iniobong A Afia; Thomas M Cahill; Cindy S Orser; Maxwell C K Leung
Journal:  Environ Health Perspect       Date:  2022-09-14       Impact factor: 11.035

3.  The Reshaping of the E-Cigarette Retail Environment: Its Evolution and Public Health Concerns.

Authors:  Carla J Berg; Albert Melena; Friedner D Wittman; Tomas Robles; Lisa Henriksen
Journal:  Int J Environ Res Public Health       Date:  2022-07-12       Impact factor: 4.614
  3 in total

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