Literature DB >> 3488482

Effect of drug therapy on compensation from vestibular injury.

S B Peppard.   

Abstract

The influence of selected drugs on compensation from unilateral labyrinthectomy was studied in the cat. The drugs investigated included: a. amphetamine, b. diazepam, c. dimenhydrinate, d. scopolamine, and e. trimethobenzamide. The most beneficial drugs for improving recovery were a stimulant (amphetamine) and a general anti-emetic (trimethobenzamide). It is postulated they had this effect by improving the overall activity level with general exercise being a known positive influence. Conversely the other drugs either had little effect on recovery or hindered it, by presumably suppressing the sensory imbalance in the vestibular system that is essential stimulus to ultimate recovery.

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Year:  1986        PMID： 3488482     DOI： 10.1002/lary.1986.96.8.878

Source DB:  PubMed          Journal:  Laryngoscope        ISSN： 0023-852X            Impact factor:   3.325


  7 in total

1.  Comparison of the therapeutic efficacy of a fixed low-dose combination of cinnarizine and dimenhydrinate with betahistine in vestibular neuritis: a randomized, double-blind, non-inferiority study.

Authors:  Arne-Wulf Scholtz; Raluca Steindl; Nicole Burchardi; Irene Bognar-Steinberg; Wolfgang Baumann
Journal:  Clin Drug Investig       Date:  2012-06-01       Impact factor: 2.859

Review 2.  Principles of vestibular physical therapy rehabilitation.

Authors:  Susan L Whitney; Patrick J Sparto
Journal:  NeuroRehabilitation       Date:  2011       Impact factor: 2.138

Review 3.  Histamine and betahistine in the treatment of vertigo: elucidation of mechanisms of action.

Authors:  M Lacour; O Sterkers
Journal:  CNS Drugs       Date:  2001       Impact factor: 5.749

Review 4.  Management of peripheral vertigo with antihistamines: New options on the horizon.

Authors:  Jonas Dyhrfjeld-Johnsen; Pierre Attali
Journal:  Br J Clin Pharmacol       Date:  2019-07-22       Impact factor: 4.335

Review 5.  Antivertigo medications and drug-induced vertigo. A pharmacological review.

Authors:  O Rascol; T C Hain; C Brefel; M Benazet; M Clanet; J L Montastruc
Journal:  Drugs       Date:  1995-11       Impact factor: 9.546

6.  Muscarinic and gamma-aminobutyric acid-ergic receptor changes during vestibular compensation. A quantitative autoradiographic study of the vestibular nuclei complex in the rat.

Authors:  L Calzà; L Giardino; M Zanni; G Galetti
Journal:  Eur Arch Otorhinolaryngol       Date:  1992       Impact factor: 2.503

7.  Betahistine Treatment in a Cat Model of Vestibular Pathology: Pharmacokinetic and Pharmacodynamic Approaches.

Authors:  Brahim Tighilet; Jacques Léonard; Isabelle Watabe; Laurence Bernard-Demanze; Michel Lacour
Journal:  Front Neurol       Date:  2018-06-11       Impact factor: 4.003
  7 in total

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