Literature DB >> 3488331

Experimental allergic encephalomyelitis induced by proteolipid apoprotein in Lewis rats.

T Yamamura, T Namikawa, M Endoh, T Kunishita, T Tabira.   

Abstract

Experimental allergic encephalomyelitis (EAE) was induced in inbred Lewis rats by sensitization with bovine white matter proteolipid apoprotein (PLP). 18-61 days after a single injection of 100 micrograms of PLP, 12 of 31 rats (39%) developed clinical EAE and 18 of 23 (78%) showed pathologic EAE with significant demyelination. Lymphocyte proliferative responses and antibodies to PLP were elevated but did not correlate with the clinical or pathologic state. This is the first demonstration of PLP-induced EAE with significant demyelination in rats and will contribute to the study of autoimmune demyelination.

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Year:  1986        PMID： 3488331     DOI： 10.1016/0165-5728(86)90027-5

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  10 in total

1.  Hemorrhagic autoimmune encephalomyelitis induced by adoptive transfer of activated semiallogeneic spleen cells into irradiated rats.

Authors:  Y Matsumoto; K Kawai; M Fujiwara
Journal:  Am J Pathol       Date:  1988-11       Impact factor: 4.307

2.  MHC haplotype-dependent regulation of MOG-induced EAE in rats.

Authors:  R Weissert; E Wallström; M K Storch; A Stefferl; J Lorentzen; H Lassmann; C Linington; T Olsson
Journal:  J Clin Invest       Date:  1998-09-15       Impact factor: 14.808

3.  Adoptively transferred experimental allergic encephalomyelitis in chimeric rats: identification of transferred cells in the lesions of the central nervous system.

Authors:  Y Matsumoto; M Fujiwara
Journal:  Immunology       Date:  1988-09       Impact factor: 7.397

Review 4.  Complement in multiple sclerosis: its role in disease and potential as a biomarker.

Authors:  G Ingram; S Hakobyan; N P Robertson; B P Morgan
Journal:  Clin Exp Immunol       Date:  2008-11-24       Impact factor: 4.330

Review 5.  Molecular pathogenesis of neuroinflammation.

Authors:  M Bradl; R Hohlfeld
Journal:  J Neurol Neurosurg Psychiatry       Date:  2003-10       Impact factor: 10.154

6.  Suppression of lymphocyte spontaneous proliferative response by proteolipid protein peptide in patients with HAM/TSP.

Authors:  T Tabira; J Inobe; K Nakahara; M Osame; T Yamamura
Journal:  Neurochem Res       Date:  1994-08       Impact factor: 3.996

Review 7.  Minireview: autoimmune responses to myelin proteolipid protein.

Authors:  R A Sobel; J M Greer; V K Kuchroo
Journal:  Neurochem Res       Date:  1994-08       Impact factor: 3.996

Review 8.  Peptide determinants of myelin proteolipid protein (PLP) in autoimmune demyelinating disease: a review.

Authors:  V K Tuohy
Journal:  Neurochem Res       Date:  1994-08       Impact factor: 3.996

9.  T cell sensitization to proteolipid protein in myelin basic protein-induced relapsing experimental allergic encephalomyelitis.

Authors:  L L Perry; E Barzaga-Gilbert; J L Trotter
Journal:  J Neuroimmunol       Date:  1991-07       Impact factor: 3.478

Review 10.  Multiple sclerosis-induced neuropathic pain: pharmacological management and pathophysiological insights from rodent EAE models.

Authors:  Nemat Khan; Maree T Smith
Journal:  Inflammopharmacology       Date:  2014-02       Impact factor: 4.473
  10 in total

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