Tawanda Chivese1, Cecilia A Hoegfeldt2, Mahmoud Werfalli3, Lili Yuen4, Hong Sun5, Suvi Karuranga5, Ninghua Li6, Akhil Gupta4, Jincy Immanuel4, Hema Divakar5, Camille E Powe7, Naomi S Levitt8, Xilin Yang6, David Simmons9. 1. Department of Population Medicine, College of medicine, QU Health, Qatar University, Doha, Qatar. 2. Department of Psychiatry, University of Oxford, Oxford, UK. 3. Department of Family and Community Medicine, Faculty of Medicine, University of Benghazi, Libya. 4. School of Medicine, Western Sydney University, Campbelltown, Australia. 5. International Diabetes Federation, Brussels, Belgium. 6. Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin, China. 7. Harvard Medical School, Boston, MA, USA; Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA. 8. Chronic Disease Initiative for Africa, Department of Medicine, University of Cape Town, Cape Town, South Africa. 9. School of Medicine, Western Sydney University, Campbelltown, Australia. Electronic address: Da.Simmons@westernsydney.edu.au.
Abstract
OBJECTIVES: To estimate the prevalence of pre-existing diabetes in pregnancy from studies published during 2010-2020. METHODS: We searched PubMed, CINAHL, Scopus and other sources for relevant data sources. The prevalence of overall pre-existing, type 1 and type 2 diabetes, by country, region and period of study was synthesised from included studies using the inverse-variance heterogeneity model and the Freeman-Tukey transformation. Heterogeneity was assessed using the I2 statistic and publication bias using funnel plots. RESULTS: We identified 2479 records, of which 42 data sources with a total of 78 943 376 women, met the eligibility criteria. The included studies were from 17 countries in North America, Europe, the Middle East and North Africa, Australasia, Asia and Africa. The lowest prevalence was in Europe (0.5%, 95 %CI 0.4-0.7) and the highest in the Middle East and North Africa (2.4%, 95 %CI 1.5-3.1). The prevalence of pre-existing diabetes doubled from 0.5% (95 %CI 0.1-1.0) to 1.0% (95 %CI 0.6-1.5) during the period 1990-2020. The pooled prevalences of pre-existing type 1 and type 2 diabetes were 0.3% (95 %CI 0.2-0.4) and 0.2% (95 %CI 0.0-0.9) respectively. CONCLUSION: While the prevalence of pre-existing diabetes in pregnancy is low, it has doubled from 1990 to 2020.
OBJECTIVES: To estimate the prevalence of pre-existing diabetes in pregnancy from studies published during 2010-2020. METHODS: We searched PubMed, CINAHL, Scopus and other sources for relevant data sources. The prevalence of overall pre-existing, type 1 and type 2 diabetes, by country, region and period of study was synthesised from included studies using the inverse-variance heterogeneity model and the Freeman-Tukey transformation. Heterogeneity was assessed using the I2 statistic and publication bias using funnel plots. RESULTS: We identified 2479 records, of which 42 data sources with a total of 78 943 376 women, met the eligibility criteria. The included studies were from 17 countries in North America, Europe, the Middle East and North Africa, Australasia, Asia and Africa. The lowest prevalence was in Europe (0.5%, 95 %CI 0.4-0.7) and the highest in the Middle East and North Africa (2.4%, 95 %CI 1.5-3.1). The prevalence of pre-existing diabetes doubled from 0.5% (95 %CI 0.1-1.0) to 1.0% (95 %CI 0.6-1.5) during the period 1990-2020. The pooled prevalences of pre-existing type 1 and type 2 diabetes were 0.3% (95 %CI 0.2-0.4) and 0.2% (95 %CI 0.0-0.9) respectively. CONCLUSION: While the prevalence of pre-existing diabetes in pregnancy is low, it has doubled from 1990 to 2020.
Authors: Philippe Oriot; Charlotte Leroy; Virginie Van Leeuw; Jean Christophe Philips; Jean François Vanderijst; Aline Vuckovic; Elena Costa; Christian Debauche; Frederic Chantraine Journal: Heliyon Date: 2022-04-12