Literature DB >> 3488254

The chromosome breakpoint at 14q32 in an ataxia telangiectasia t(14;14) T cell clone is different from the 14q32 breakpoint in Burkitts and an inv(14) T cell lymphoma.

A A Kennaugh, S V Butterworth, R Hollis, R Baer, T H Rabbitts, A M Taylor.   

Abstract

The T cell receptor alpha chain gene locus and the immunoglobulin heavy chain gene locus (IgH) have previously been mapped to the q11 and q32 positions respectively of the human chromosome 14. Both of these sites are also common breakpoints in lymphocytes from ataxia telangiectasia (A-T) patients. Using in situ hybridisation we show that the 14q32 breakpoint in an A-T non-leukaemic T cell clone with t(14;14) translocation, lies outside the IgH locus and proximal to it with respect to the centromere. The 14q11-14qter segment of the homologous chromosome 14 carrying the constant gene region of the alpha chain locus is translocated to this 14q32 position.

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Year:  1986        PMID： 3488254     DOI： 10.1007/BF00401239

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  25 in total

1.  Localization of the human alpha-globin gene cluster to the short arm of chromosome 16 (16p12-16pter) by hybridization in situ.

Authors:  P Barton; S Malcolm; C Murphy; M A Ferguson-Smith
Journal:  J Mol Biol       Date:  1982-04-05       Impact factor: 5.469

2.  Translocation of immunoglobulin VH genes in Burkitt lymphoma.

Authors:  J Erikson; J Finan; P C Nowell; C M Croce
Journal:  Proc Natl Acad Sci U S A       Date:  1982-09       Impact factor: 11.205

3.  High frequencies of inversions and translocations of chromosomes 7 and 14 in ataxia telangiectasia.

Authors:  A Aurias; B Dutrillaux; D Buriot; J Lejeune
Journal:  Mutat Res       Date:  1980-02       Impact factor: 2.433

4.  Common region on chromosome 14 in T-cell leukemia and lymphoma.

Authors:  F Hecht; R Morgan; B K Hecht; S D Smith
Journal:  Science       Date:  1984-12-21       Impact factor: 47.728

5.  Atypical lymphoid leukemia in ataxia telangiectasia.

Authors:  R Levitt; R V Pierre; W L White; R G Siekert
Journal:  Blood       Date:  1978-11       Impact factor: 22.113

6.  Chromosomal aberrations in a case of T-cell CLL with concomitant IgA myeloma.

Authors:  L Zech; L Hammarström; C I Smith
Journal:  Int J Cancer       Date:  1983-10-15       Impact factor: 7.396

7.  Human immunoglobulin heavy chain genes: evolutionary comparisons of C mu, C delta and C gamma genes and associated switch sequences.

Authors:  T H Rabbitts; A Forster; C P Milstein
Journal:  Nucleic Acids Res       Date:  1981-09-25       Impact factor: 16.971

8.  Breakpoints in the human T-cell antigen receptor alpha-chain locus in two T-cell leukaemia patients with chromosomal translocations.

Authors:  W H Lewis; E E Michalopoulos; D L Williams; M D Minden; T W Mak
Journal:  Nature       Date:  1985 Oct 10-16       Impact factor: 49.962

9.  Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells.

Authors:  R Taub; I Kirsch; C Morton; G Lenoir; D Swan; S Tronick; S Aaronson; P Leder
Journal:  Proc Natl Acad Sci U S A       Date:  1982-12       Impact factor: 11.205

10.  Gene for alpha-chain of human T-cell receptor: location on chromosome 14 region involved in T-cell neoplasms.

Authors:  C M Croce; M Isobe; A Palumbo; J Puck; J Ming; D Tweardy; J Erikson; M Davis; G Rovera
Journal:  Science       Date:  1985-03-01       Impact factor: 47.728
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  12 in total

1.  Fine mapping of the chromosome 11q22-23 region using PFGE, linkage and haplotype analysis; localization of the gene for ataxia telangiectasia to a 5cM region flanked by NCAM/DRD2 and STMY/CJ52.75, phi 2.22.

Authors:  C M McConville; C J Formstone; D Hernandez; J Thick; A M Taylor
Journal:  Nucleic Acids Res       Date:  1990-08-11       Impact factor: 16.971

2.  Molecular analysis of a t(14;14) translocation in leukemic T-cells of an ataxia telangiectasia patient.

Authors:  G Russo; M Isobe; R Gatti; J Finan; O Batuman; K Huebner; P C Nowell; C M Croce
Journal:  Proc Natl Acad Sci U S A       Date:  1989-01       Impact factor: 11.205

3.  Molecular characterization of different ataxia telangiectasia T-cell clones. I. A common breakpoint at the 14q11.2 band splits the T-cell receptor alpha-chain gene.

Authors:  M H Stern; F R Zhang; C Griscelli; G Thomas; A Aurias
Journal:  Hum Genet       Date:  1988-01       Impact factor: 4.132

4.  Juxtaposition of the T-cell receptor alpha-chain locus (14q11) and a region (14q32) of potential importance in leukemogenesis by a 14;14 translocation in a patient with T-cell chronic lymphocytic leukemia and ataxia-telangiectasia.

Authors:  M P Davey; V Bertness; K Nakahara; J P Johnson; O W McBride; T A Waldmann; I R Kirsch
Journal:  Proc Natl Acad Sci U S A       Date:  1988-12       Impact factor: 11.205

5.  Analysis of a T-cell tumor-specific breakpoint cluster at human chromosome 14q32.

Authors:  L Mengle-Gaw; D G Albertson; P D Sherrington; T H Rabbitts
Journal:  Proc Natl Acad Sci U S A       Date:  1988-12       Impact factor: 11.205

6.  The breakpoint of an inversion of chromosome 14 in a T-cell leukemia: sequences downstream of the immunoglobulin heavy chain locus are implicated in tumorigenesis.

Authors:  R Baer; A Heppell; A M Taylor; P H Rabbitts; B Boullier; T H Rabbitts
Journal:  Proc Natl Acad Sci U S A       Date:  1987-12       Impact factor: 11.205

7.  Molecular characterization of ataxia telangiectasia T cell clones. III. Mapping the 14q32.1 distal breakpoint.

Authors:  M H Stern; F R Zhang; G Thomas; C Griscelli; A Aurias
Journal:  Hum Genet       Date:  1988-12       Impact factor: 4.132

8.  Inv(14) with distal breakpoint in 14q32.1 in three cases of T cell lymphoma.

Authors:  B Schlegelberger; A C Feller; H H Wacker; J Lohmeyer; W Grote
Journal:  Hum Genet       Date:  1990-06       Impact factor: 4.132

9.  Growth of large chromosomally abnormal T cell clones in ataxia telangiectasia patients is associated with translocation at 14q11. A model for other T cell neoplasia.

Authors:  R J Hollis; A A Kennaugh; S V Butterworth; A M Taylor
Journal:  Hum Genet       Date:  1987-08       Impact factor: 4.132

10.  Molecular characterization of ataxia telangiectasia T cell clones. II. The clonal inv(14) in ataxia telangiectasia differs from the inv(14) in T cell lymphoma.

Authors:  F Zhang; M H Stern; G Thomas; A Aurias
Journal:  Hum Genet       Date:  1988-04       Impact factor: 4.132
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