Literature DB >> 3488229

Suppression of the induction of delayed hypersensitivity in rats by repetitive morphine treatments.

N R Pellis, C Harper, N Dafny.   

Abstract

Previous in vitro experiments suggest that lymphocyte function may be altered in the presence of opiates. The effect of morphine treatment upon specific T lymphocyte function in vivo was investigated in rats. Following morphine treatment, rats were incapable of responding to immunization with the T-dependent antigens of Mycobacterium bovis, strain BCG. The absence of a delayed hypersensitive skin response to tuberculin in chronic morphine-treated rats supports the hypothesis that opiates may interact with the cells of the immune system. A potential communication between the nervous system and cells of the immune system is proposed.

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Year:  1986        PMID： 3488229     DOI： 10.1016/0014-4886(86)90148-2

Source DB:  PubMed          Journal:  Exp Neurol        ISSN： 0014-4886            Impact factor:   5.330


  9 in total

1.  Stress and skin leukocyte trafficking as a dual-stage process.

Authors:  Elad Neeman; Lee Shaashua; Marganit Benish; Gayle G Page; Oded Zmora; Shamgar Ben-Eliyahu
Journal:  Brain Behav Immun       Date:  2011-09-19       Impact factor: 7.217

Review 2.  Effects of opioid tolerance and withdrawal on the immune system.

Authors:  Toby K Eisenstein; Rahil T Rahim; Pu Feng; Nita K Thingalaya; Joseph J Meissler
Journal:  J Neuroimmune Pharmacol       Date:  2006-05-23       Impact factor: 4.147

3.  Opiates and the development of post-injury complications: a review.

Authors:  Martin G Schwacha
Journal:  Int J Clin Exp Med       Date:  2008-01-20

4.  Immunomodulatory activity of mu- and kappa-selective opioid agonists.

Authors:  D D Taub; T K Eisenstein; E B Geller; M W Adler; T J Rogers
Journal:  Proc Natl Acad Sci U S A       Date:  1991-01-15       Impact factor: 11.205

5.  Heterologous desensitization of opioid receptors by chemokines inhibits chemotaxis and enhances the perception of pain.

Authors:  Imre Szabo; Xiao-Hong Chen; Li Xin; Martin W Adler; O M Z Howard; Joost J Oppenheim; Thomas J Rogers
Journal:  Proc Natl Acad Sci U S A       Date:  2002-07-18       Impact factor: 11.205

6.  Decreased spinal cord opioid receptor mRNA expression and antinociception in a Theiler's murine encephalomyelitis virus model of multiple sclerosis.

Authors:  Jessica L Lynch; Jeremy F Alley; Lori Wellman; Alvin J Beitz
Journal:  Brain Res       Date:  2007-11-28       Impact factor: 3.252

7.  Primary role for Gi protein signaling in the regulation of interleukin 12 production and the induction of T helper cell type 1 responses.

Authors:  J He; S Gurunathan; A Iwasaki; B Ash-Shaheed; B L Kelsall
Journal:  J Exp Med       Date:  2000-05-01       Impact factor: 14.307

Review 8.  The Role of Opioid Receptors in Immune System Function.

Authors:  Toby K Eisenstein
Journal:  Front Immunol       Date:  2019-12-20       Impact factor: 7.561

9.  Opiates transdeactivate chemokine receptors: delta and mu opiate receptor-mediated heterologous desensitization.

Authors:  M C Grimm; A Ben-Baruch; D D Taub; O M Howard; J H Resau; J M Wang; H Ali; R Richardson; R Snyderman; J J Oppenheim
Journal:  J Exp Med       Date:  1998-07-20       Impact factor: 14.307
  9 in total

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