Literature DB >> 3488223

A second form of human calcitonin gene-related peptide which is a potent vasodilator.

S D Brain, I MacIntyre, T J Williams.   

Abstract

A recently predicted form of human calcitonin gene-related peptide, (beta CGRP) exhibits potent vasodilator activity in rabbit skin with a similar potency to the form of human CGRP originally described (alpha CGRP). Both peptides, because of their vasodilator activity, cause a potentiation of inflammatory oedema induced by mediators of increased vascular permeability. The results demonstrate that changes can be made at certain positions in the amino acid sequence of human CGRP without loss of vasodilator activity.

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Year:  1986        PMID： 3488223     DOI： 10.1016/0014-2999(86)90238-4

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  11 in total

Review 1.  Peptides from the calcitonin genes: molecular genetics, structure and function.

Authors:  L H Breimer; I MacIntyre; M Zaidi
Journal:  Biochem J       Date:  1988-10-15       Impact factor: 3.857

2.  Structure-activity relationship of human calcitonin-gene-related peptide.

Authors:  M Zaidi; S D Brain; J R Tippins; V Di Marzo; B S Moonga; T J Chambers; H R Morris; I MacIntyre
Journal:  Biochem J       Date:  1990-08-01       Impact factor: 3.857

3.  Regional haemodynamic effects of human alpha- and beta-calcitonin gene-related peptide in conscious Wistar rats.

Authors:  S M Gardiner; A M Compton; T Bennett
Journal:  Br J Pharmacol       Date:  1989-12       Impact factor: 8.739

4.  Cloning, characterization, and expression of a human calcitonin receptor from an ovarian carcinoma cell line.

Authors:  A H Gorn; H Y Lin; M Yamin; P E Auron; M R Flannery; D R Tapp; C A Manning; H F Lodish; S M Krane; S R Goldring
Journal:  J Clin Invest       Date:  1992-11       Impact factor: 14.808

5.  Time-dependent synergistic interactions between the vasodilator neuropeptide, calcitonin gene-related peptide (CGRP) and mediators of inflammation.

Authors:  T L Buckley; S D Brain; M Rampart; T J Williams
Journal:  Br J Pharmacol       Date:  1991-06       Impact factor: 8.739

6.  A calcitonin gene-related peptide (CGRP) antagonist (CGRP8-37) inhibits microvascular responses induced by CGRP and capsaicin in skin.

Authors:  S R Hughes; S D Brain
Journal:  Br J Pharmacol       Date:  1991-11       Impact factor: 8.739

7.  Carbamylcholine- and 5-hydroxytryptamine-induced contraction in rat isolated airways: inhibition by calcitonin gene-related peptide.

Authors:  A Cadieux; C Lanoue; P Sirois; J Barabé
Journal:  Br J Pharmacol       Date:  1990-09       Impact factor: 8.739

Review 8.  Peptides in the mammalian cardiovascular system.

Authors:  J Wharton; S Gulbenkian
Journal:  Experientia       Date:  1987-07-15

9.  Calcitonin gene-related peptide immunoreactivity in airway epithelial cells of the human fetus and infant.

Authors:  D E Johnson; J D Wobken
Journal:  Cell Tissue Res       Date:  1987-12       Impact factor: 5.249

10.  Protective roles of alpha-calcitonin and beta-calcitonin gene-related peptide in spontaneous and experimentally induced colitis.

Authors:  Brent J Thompson; Mary K Washington; Usha Kurre; Minati Singh; Elizabeth Y Rula; Ronald B Emeson
Journal:  Dig Dis Sci       Date:  2007-05-26       Impact factor: 3.199
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