Ludovic Tréluyer1, Pierre-Henri Jarreau1,2, Laetitia Marchand-Martin1, Valerie Benhammou1, Alexandra Nuytten3,4, Patrick Berquin5, Stéphane Marret6, Véronique Pierrat1,3, Pierre-Yves Ancel1,7, Héloïse Torchin1,2. 1. Epidemiology and Statistics Research Center/CRESS, INSERM, INRAE, University of Paris, Paris, France. 2. Department of Neonatal Medicine, Cochin-Port Royal Hospital, FHU PREMA, AP-HP Centre, Paris, France. 3. Department of Neonatal Medicine, CHU Lille, Jeanne de Flandre Hospital, Lille, France. 4. CHU Lille, ULR 2694 - METRICS, Évaluation des Technologies de Santé et des Pratiques Médicales, University of Lille, Lille, France. 5. Department of Pediatric Neurology, Amiens-Picardie University Hospital, University of Picardie Jules Verne, Amiens, France. 6. Department of Neonatal Pediatrics, Intensive Care, and Neuropediatrics, Rouen University Hospital, Rouen, France and INSERM Unit 1245, Team Perinatal Handicap, School of Medicine of Rouen, Normandy University, Normandy, France. 7. Clinical Research Unit, Center for Clinical Investigation P1419, Assitance Publique Hôpitaux de Paris, Paris, France.
Abstract
BACKGROUND: Overall and respiratory management of preterm children are constantly evolving, which might have changed both the pathophysiology and neurodevelopmental consequences of bronchopulmonary dysplasia (BPD). OBJECTIVES: The objective of this study is to determine whether the previously shown association between BPD and risk of developmental delay persists. METHODS: The study population was children born before 32 weeks' gestation from the French prospective cohort EPIPAGE-2. The exposure was BPD assessed at 36 weeks' postmenstrual age. The main outcome was risk of developmental delay defined by an Age & Stages Questionnaires (ASQ) score below threshold at 24 months' corrected age. RESULTS: The analyzed population included 2,706 children. Among those with available ASQ score, 196/1,587 had BPD and 671/1,587 had an ASQ score below threshold. BPD was associated with an ASQ score below threshold (odds ratio 1.52, 95% confidence interval 1.11-2.08; p = 0.008). CONCLUSIONS: BPD was strongly associated with risk of developmental delay.
BACKGROUND: Overall and respiratory management of preterm children are constantly evolving, which might have changed both the pathophysiology and neurodevelopmental consequences of bronchopulmonary dysplasia (BPD). OBJECTIVES: The objective of this study is to determine whether the previously shown association between BPD and risk of developmental delay persists. METHODS: The study population was children born before 32 weeks' gestation from the French prospective cohort EPIPAGE-2. The exposure was BPD assessed at 36 weeks' postmenstrual age. The main outcome was risk of developmental delay defined by an Age & Stages Questionnaires (ASQ) score below threshold at 24 months' corrected age. RESULTS: The analyzed population included 2,706 children. Among those with available ASQ score, 196/1,587 had BPD and 671/1,587 had an ASQ score below threshold. BPD was associated with an ASQ score below threshold (odds ratio 1.52, 95% confidence interval 1.11-2.08; p = 0.008). CONCLUSIONS: BPD was strongly associated with risk of developmental delay.