| Literature DB >> 3487928 |
R L Wortmann, J A Veum, H S Cheung.
Abstract
An in vitro model of ADA deficiency is selectively toxic to cartilage from immature rabbits with a greater effect on growth plate than articular cartilage. The selective toxicity observed appears to be the consequence of ATP depletion. These results support the hypothesis that the chondro-osseous dysplasia observed in patients with ADA deficiency is caused by the disordered metabolism that results from the enzyme deficiency.Entities:
Mesh：
Substances：
Year: 1986 PMID： 3487928 DOI： 10.1007/978-1-4684-5104-7_13
Source DB: PubMed Journal: Adv Exp Med Biol ISSN： 0065-2598 Impact factor: 2.622