Anna Pink1, Janina Krell-Roesch2,3, Jeremy A Syrjanen2, Maria Vassilaki2, Val J Lowe4, Prashanthi Vemuri4, Gorazd B Stokin5, Teresa J Christianson2, Walter K Kremers2, Clifford R Jack4, David S Knopman6, Ronald C Petersen2,6, Yonas E Geda7. 1. Department of Geriatrics, Paracelsus Medical University, Salzburg, Austria. 2. Department of Quantitative Health Sciences, Mayo Clinic Rochester, Rochester, Minnesota, USA. 3. Institute of Sports and Sports Science, Karlsruhe Institute of Technology, Karlsruhe, Germany. 4. Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA. 5. International Clinical Research Center/St. Anne Hospital, Brno, Czech Republic. 6. Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA. 7. Department of Neurology, Barrow Neurological Institute, Phoenix, Arizona, USA.
Abstract
INTRODUCTION: We investigated the longitudinal relationship between cortical amyloid deposition, anxiety, and depression and the risk of incident mild cognitive impairment (MCI). METHODS: We followed 1440 community-dwelling, cognitively unimpaired individuals aged ≥ 50 years for a median of 5.5 years. Clinical anxiety and depression were assessed using Beck Anxiety and Depression Inventories (BAI, BDI-II). Cortical amyloid beta (Aβ) was measured by Pittsburgh compound B positron emission tomography (PiB-PET) and elevated deposition (PiB+) was defined as standardized uptake value ratio ≥ 1.48. We calculated Cox proportional hazards models with age as the time scale, adjusted for sex, education, and medical comorbidity. RESULTS: Cortical Aβ deposition (PiB+) independent of anxiety (BAI ≥ 10) or depression (BDI-II ≥ 13) increased the risk of MCI. There was a significant additive interaction between PiB+ and anxiety (joint effect hazard ratio 6.77; 95% confidence interval 3.58-12.79; P = .031) that is, being PiB+ and having anxiety further amplified the risk of MCI. DISCUSSION: Anxiety modified the association between PiB+ and incident MCI.
INTRODUCTION: We investigated the longitudinal relationship between cortical amyloid deposition, anxiety, and depression and the risk of incident mild cognitive impairment (MCI). METHODS: We followed 1440 community-dwelling, cognitively unimpaired individuals aged ≥ 50 years for a median of 5.5 years. Clinical anxiety and depression were assessed using Beck Anxiety and Depression Inventories (BAI, BDI-II). Cortical amyloid beta (Aβ) was measured by Pittsburgh compound B positron emission tomography (PiB-PET) and elevated deposition (PiB+) was defined as standardized uptake value ratio ≥ 1.48. We calculated Cox proportional hazards models with age as the time scale, adjusted for sex, education, and medical comorbidity. RESULTS: Cortical Aβ deposition (PiB+) independent of anxiety (BAI ≥ 10) or depression (BDI-II ≥ 13) increased the risk of MCI. There was a significant additive interaction between PiB+ and anxiety (joint effect hazard ratio 6.77; 95% confidence interval 3.58-12.79; P = .031) that is, being PiB+ and having anxiety further amplified the risk of MCI. DISCUSSION: Anxiety modified the association between PiB+ and incident MCI.
Authors: Terence W H Chong; Scherazad Kootar; Helen Wilding; Sarah Berriman; Eleanor Curran; Kay L Cox; Alex Bahar-Fuchs; Ruth Peters; Kaarin J Anstey; Christina Bryant; Nicola T Lautenschlager Journal: Ther Adv Psychopharmacol Date: 2022-07-07