A photochemical approach to anchor Au NPs on MXene as a prominent SERS substrate for ultrasensitive detection of chlorpromazine.

As a novel two-dimensional (2D) material, metal carbide (MXene) has been identified as a hotspot research topic in the field of surface-enhanced Raman spectroscopy (SERS). Herein, we report the increment of SERS activity of titanium carbide (TiC) by incorporation of gold nanoparticles (Au NPs) by a facile photoreduction process for the detection of antipsychotic drug. TiC anchored with Au NPs produce a remarkable SERS enhancement by the synergistic action of chemical and electromagnetic mechanisms. The hotspots are formed in the nanometer-scale gaps between Au NPs on the TiC surface for the effective interaction with probe molecules. The proposed TiC/Au-NPs SERS substrate was employed for the detection of chlorpromazine (CPZ) with the wide linear range of 10-1-10-10 M and the ultra-low limit of detection of 3.92 × 10-11 M. Besides, the SERS effect of the optimized TiC/Au-NPs for the 532 nm excitation exhibits the enhancement factor in the order of 109 with the relative standard deviation of < 13% for the uniformity and < 8.80% for the reproducibility. To ensure the practical feasibility of the proposed TiC/Au-NPs SERS substrate, the spike and recovery method was used for the detection of CPZ in human biological fluids like urine and saliva. This work can open up a new approach to improve the SERS activity of MXene-based SERS substrate for practical applications, especially the determination of antipsychotic drugs in environmental pollution management.