Christine R Langton1, Brian W Whitcomb1, Alexandra C Purdue-Smithe2, Lynnette L Sievert3, Susan E Hankinson1,4, JoAnn E Manson4,5,6, Bernard A Rosner4,7, Elizabeth R Bertone-Johnson1,8. 1. Department of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA. 2. Division of Women's Health, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA. 3. Department of Anthropology, University of Massachusetts, Amherst, MA. 4. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA. 5. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA. 6. Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA. 7. Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA. 8. Department of Health Promotion and Policy, School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA.
Abstract
OBJECTIVE: Oral contraceptives (OCs) and tubal ligation are commonly used methods of contraception that may impact ovarian function. Few studies have examined the association of these factors with antimüllerian hormone (AMH), a marker of ovarian aging. METHODS: We examined the association of OC use and tubal ligation with AMH in the Nurses' Health Study II prospective cohort among a subset of 1,420 premenopausal participants who provided a blood sample in 1996-1999. History of OC use and tubal ligation were reported in 1989 and updated every 2 years until blood collection. We utilized generalized linear models to assess whether mean AMH levels varied by duration of and age at first use of OCs and history, age, and type of tubal ligation. RESULTS: In multivariable models adjusted for smoking, reproductive events, and other lifestyle factors, we observed a significant, inverse association between duration of OC use and mean AMH levels (P for trend = 0.036). Compared to women without a tubal ligation, AMH levels were significantly lower when the procedure included a clip, ring, or band (1.04 ng/ml vs 1.72 ng/ml, P < 0.01). AMH levels were not associated with age at first use of OCs or age at tubal ligation. CONCLUSIONS: Our analysis found an association between duration of OC use and certain types of tubal ligation with mean AMH levels. Further research is warranted to confirm the long-term association of these widely used contraceptive methods with AMH.
OBJECTIVE: Oral contraceptives (OCs) and tubal ligation are commonly used methods of contraception that may impact ovarian function. Few studies have examined the association of these factors with antimüllerian hormone (AMH), a marker of ovarian aging. METHODS: We examined the association of OC use and tubal ligation with AMH in the Nurses' Health Study II prospective cohort among a subset of 1,420 premenopausal participants who provided a blood sample in 1996-1999. History of OC use and tubal ligation were reported in 1989 and updated every 2 years until blood collection. We utilized generalized linear models to assess whether mean AMH levels varied by duration of and age at first use of OCs and history, age, and type of tubal ligation. RESULTS: In multivariable models adjusted for smoking, reproductive events, and other lifestyle factors, we observed a significant, inverse association between duration of OC use and mean AMH levels (P for trend = 0.036). Compared to women without a tubal ligation, AMH levels were significantly lower when the procedure included a clip, ring, or band (1.04 ng/ml vs 1.72 ng/ml, P < 0.01). AMH levels were not associated with age at first use of OCs or age at tubal ligation. CONCLUSIONS: Our analysis found an association between duration of OC use and certain types of tubal ligation with mean AMH levels. Further research is warranted to confirm the long-term association of these widely used contraceptive methods with AMH.
Authors: Lynne T Shuster; Deborah J Rhodes; Bobbie S Gostout; Brandon R Grossardt; Walter A Rocca Journal: Maturitas Date: 2009-09-05 Impact factor: 4.342
Authors: M H van den Berg; E van Dulmen-den Broeder; A Overbeek; J W R Twisk; R Schats; F E van Leeuwen; G J Kaspers; C B Lambalk Journal: Hum Reprod Date: 2010-03-27 Impact factor: 6.918
Authors: M Dólleman; W M M Verschuren; M J C Eijkemans; M E T Dollé; E H J M Jansen; F J M Broekmans; Y T van der Schouw Journal: J Clin Endocrinol Metab Date: 2013-03-26 Impact factor: 5.958
Authors: J G Bentzen; J L Forman; A Pinborg; Ø Lidegaard; E C Larsen; L Friis-Hansen; T H Johannsen; A Nyboe Andersen Journal: Reprod Biomed Online Date: 2012-09-16 Impact factor: 3.828
Authors: Sonya M Schuh-Huerta; Nicholas A Johnson; Mitchell P Rosen; Barbara Sternfeld; Marcelle I Cedars; Renee A Reijo Pera Journal: Hum Reprod Date: 2011-11-24 Impact factor: 6.918
Authors: Rebecca L Birtch; Angela R Baerwald; Olufemi A Olatunbosun; Roger A Pierson Journal: Reprod Biol Endocrinol Date: 2005-04-13 Impact factor: 5.211
Authors: Didier Dewailly; Claus Yding Andersen; Adam Balen; Frank Broekmans; Nafi Dilaver; Renato Fanchin; Georg Griesinger; Tom W Kelsey; Antonio La Marca; Cornelius Lambalk; Helen Mason; Scott M Nelson; Jenny A Visser; W Hamish Wallace; Richard A Anderson Journal: Hum Reprod Update Date: 2014-01-14 Impact factor: 15.610