| Literature DB >> 34870779 |
Zhongxiao Lin1,2,3, Jishuo Chang1,3, Xinzhi Li2, Jianglin Wang1, Xiaodan Wu1, Xiaoyan Liu2,4, YiZhun Zhu5, Xi-Yong Yu6,7.
Abstract
Epigenetic modifications viz. DNA methylation, histone modifications, and RNA-based alterations play a crucial role in the development of cardiovascular diseases. In this study, we investigated DNA methylation with an aim to reveal the epigenetic etiology of heart failure. Sprague-Dawley rats surviving myocardial infarction developed acute heart failure in 1 week. Genomic DNA methylation changes were profiled by bisulfite sequencing, and gene expression levels were analyzed by RNA-seq in failing and sham-operation hearts. A total of 3480 differentially methylated genes in the promoter regions including transcriptional start site and 1934 transcriptome-altered genes were identified in the defected hearts. Common differential genes were enriched by the gene ontology, Kyoto Encyclopedia of Genes and Genomes pathway, and protein-protein interaction for HF phenotypes. Among these, Mettl11b, HDAC3, HDAC11, ubiquitination-related genes, and snoRNAs are new epigenetic classifiers that had not been reported yet, which may be important regulators in HF.Entities:
Keywords: DNA methylation; Epigenetic; Heart failure; Promoter; Transcriptome
Mesh：
Year: 2021 PMID： 34870779 DOI： 10.1007/s10142-021-00813-9
Source DB: PubMed Journal: Funct Integr Genomics ISSN： 1438-793X Impact factor: 3.410