Literature DB >> 3486843

Immunoprofile of reactions in leprosy.

V N Sehgal, R K Gautam, V K Sharma.   

Abstract

The immunologic profile during erythema nodosum leprosum (ENL) revealed increased percentage and absolute count of B-lymphocytes, in addition to considerably lowered levels of complement component C3. Serum immunoglobulins--IgG, IgA, and IgM--were significantly raised after subsidence of ENL, whereas upgrading reaction showed an increase of absolute count of total T lymphocytes and percentage and count of B-lymphocytes. In addition, a raised serum IgM level was noted after regression of ENL. Downgrading reaction demonstrated a decreased percentage of early T-lymphocytes and raised the absolute count of B-lymphocytes. Serum IgA levels were found to be increased after amelioration of ENL.

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Year:  1986        PMID: 3486843     DOI: 10.1111/j.1365-4362.1986.tb02233.x

Source DB:  PubMed          Journal:  Int J Dermatol        ISSN: 0011-9059            Impact factor:   2.736


  4 in total

1.  Increased activated memory B-cells in the peripheral blood of patients with erythema nodosum leprosum reactions.

Authors:  Edessa Negera; Stephen L Walker; Yonas Bekele; Hazel M Dockrell; Diana N Lockwood
Journal:  PLoS Negl Trop Dis       Date:  2017-12-18

Review 2.  A Systematic Review of Immunological Studies of Erythema Nodosum Leprosum.

Authors:  Anastasia Polycarpou; Stephen L Walker; Diana N J Lockwood
Journal:  Front Immunol       Date:  2017-03-13       Impact factor: 7.561

3.  Editorial: The Role of Biomarkers in the Immunopathology and Diagnosis of Immune Exacerbations in Leprosy-New Frontiers to Manage This Neglected Disease.

Authors:  Paulo R Z Antas; Dilvani O Santos
Journal:  Front Med (Lausanne)       Date:  2022-03-25

4.  Differential Expression of IFN-γ, IL-10, TLR1, and TLR2 and Their Potential Effects on Downgrading Leprosy Reaction and Erythema Nodosum Leprosum.

Authors:  Douglas Eulálio Antunes; Isabela Maria Bernardes Goulart; Mayara Ingrid Sousa Lima; Patrícia Terra Alves; Paula Cristina Brígido Tavares; Luiz Ricardo Goulart
Journal:  J Immunol Res       Date:  2019-11-07       Impact factor: 4.818

  4 in total

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