Literature DB >> 3486773

Human and rat alpha-CGRP but not calcitonin cause mesenteric vasodilatation in rats.

I Marshall, S J Al-Kazwini, J J Holman, R K Craig.   

Abstract

A single gene encodes both calcitonin and the calcitonin gene-related peptide (CGRP). Human and rat alpha-CGRP were compared with sodium nitroprusside in the rat and rabbit isolated mesenteric vascular preparation perfused at constant flow. In the presence of the vasoconstrictor noradrenaline (10(-5) M), rat alpha-CGRP was about 10 times as potent as either human alpha-CGRP or sodium nitroprusside as a vasodilator in the rat mesenteric vasculature. In the rabbit mesenteric vasculature the order of potency was rat alpha-CGRP greater than human alpha-CGRP greater than sodium nitroprusside. Human and salmon calcitonin showed no vasodilator activity at doses 100 times greater than human alpha-CGRP. These results show that human and rat alpha-CGRP are potent vasodilators in the mesenteric vasculature, an effect not mimicked by the alternative gene product, the plasma calcium lowering hormone calcitonin.

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Year:  1986        PMID： 3486773     DOI： 10.1016/0014-2999(86)90662-x

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  20 in total

1.  Receptors mediating CGRP-induced relaxation in the rat isolated thoracic aorta and porcine isolated coronary artery differentiated by h(alpha) CGRP(8-37).

Authors:  F M Wisskirchen; D W Gray; I Marshall
Journal:  Br J Pharmacol       Date:  1999-09       Impact factor: 8.739

2.  Haemodynamic effects of the bacterial quorum sensing signal molecule, N-(3-oxododecanoyl)-L-homoserine lactone, in conscious, normal and endotoxaemic rats.

Authors:  S M Gardiner; S R Chhabra; C Harty; P Williams; D I Pritchard; B W Bycroft; T Bennett
Journal:  Br J Pharmacol       Date:  2001-08       Impact factor: 8.739

3.  Vasodilating effects of human and rat calcitonin gene-related peptides in isolated porcine coronary arteries.

Authors:  T Shoji; H Ishihara; T Ishikawa; A Saito; K Goto
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-10       Impact factor: 3.000

4.  Endothelium and the vasodilator action of rat calcitonin gene-related peptide (CGRP).

Authors:  G C Grace; G J Dusting; B E Kemp; T J Martin
Journal:  Br J Pharmacol       Date:  1987-08       Impact factor: 8.739

5.  The relaxant properties of human calcitonin gene-related peptide on vascular and extravascular capsular) smooth muscle of the isolated blood-perfused spleen of the anaesthetized dog.

Authors:  P G Withrington
Journal:  Br J Pharmacol       Date:  1989-04       Impact factor: 8.739

6.  Conformational restraints revealing bioactive beta-bend structures for halpha CGRP8-37 at the CGRP2 receptor of the rat prostatic vas deferens.

Authors:  F M Wisskirchen; P M Doyle; S L Gough; C J Harris; I Marshall
Journal:  Br J Pharmacol       Date:  1999-03       Impact factor: 8.739

7.  Structure-activity relationship of human calcitonin-gene-related peptide.

Authors:  M Zaidi; S D Brain; J R Tippins; V Di Marzo; B S Moonga; T J Chambers; H R Morris; I MacIntyre
Journal:  Biochem J       Date:  1990-08-01       Impact factor: 3.857

8.  A quantitative ultrastructural investigation of tyrosine hydroxylase-immunoreactive axons in the hairy skin of the guinea pig.

Authors:  S Roth; W Kummer
Journal:  Anat Embryol (Berl)       Date:  1994-08

9.  Human alpha-calcitonin gene-related peptide (CGRP) is a potent vasodilator in human mesenteric vasculature.

Authors:  I Marshall; S J Al-Kazwini; J J Holman; R K Craig
Journal:  Br J Clin Pharmacol       Date:  1988-12       Impact factor: 4.335

10.  The actions of two sensory neuropeptides, substance P and calcitonin gene-related peptide, on the canine hepatic arterial and portal vascular beds.

Authors:  P G Withrington
Journal:  Br J Pharmacol       Date:  1992-10       Impact factor: 8.739
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