Literature DB >> 3486730

Analysis of interleukin 1 mediated radioprotection.

I Manori, A Kushilevsky, Y Weinstein.   

Abstract

The potential value of interleukin 1 (IL-1) containing supernatants as a radioprotective agent was evaluated. It was found that the response of irradiated thymocytes to mitogens was partially restored if IL-1 containing supernatants was included in the culture medium immediately after irradiation. A delay of 24 h in the addition of IL-1 and mitogen abrogated the radioprotection effect. Under the same conditions IL-2 containing supernatants were effective, suggesting that the dose modifying effect of IL-1 acts through induction of IL-2 elaboration. The results of the present study may be important in cases where it is necessary to restore depressed immune response resulting from irradiation accidents or radiotherapy.

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Year:  1986        PMID： 3486730      PMCID： PMC1577567     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  9 in total

1.  Letter: The lymphocyte response to phytohaemagglutinin after in vitro irradiation.

Authors:  J Braeman; J L Moore
Journal:  Br J Radiol       Date:  1974-05       Impact factor: 3.039

2.  The surviving lymphocyte "in vitro" after radiation stress: a biologic dosimeter.

Authors:  J Weijer; D L Weijer
Journal:  J Can Assoc Radiol       Date:  1973-03

3.  T cell growth factor: parameters of production and a quantitative microassay for activity.

Authors:  S Gillis; M M Ferm; W Ou; K A Smith
Journal:  J Immunol       Date:  1978-06       Impact factor: 5.422

4.  Radiosensitivity of isolated subsets of human lymphocytes (E+, OKT4+, OKT8+): protective role of monocytes and monokines.

Authors:  I Manori; A Kushilevsky; S Segal; Y Weinstein
Journal:  Clin Exp Immunol       Date:  1984-11       Impact factor: 4.330

5.  Lymphocyte activating factor promotes T-cell growth factor production by cloned murine lymphoma cells.

Authors:  K A Smith; K J Gilbride; M F Favata
Journal:  Nature       Date:  1980-10-30       Impact factor: 49.962

Review 6.  Interleukin 2: a class of T cell growth factors.

Authors:  J Watson; D Mochizuki
Journal:  Immunol Rev       Date:  1980       Impact factor: 12.988

Review 7.  The radiobiology of mammalian cells.

Authors:  M A Ritter
Journal:  Semin Oncol       Date:  1981-03       Impact factor: 4.929

8.  Effect of radiation on the production of interleukins and T-lymphocyte activities.

Authors:  I Manori; A Kushelevsky; S Segal; Y Weinstein
Journal:  J Natl Cancer Inst       Date:  1985-06       Impact factor: 13.506

9.  Potentiation of the T-lymphocyte response to mitogens. II. The cellular source of potentiating mediator(s).

Authors:  I Gery; B H Waksman
Journal:  J Exp Med       Date:  1972-07-01       Impact factor: 14.307
  9 in total
  1 in total

1.  Characterization of mouse thymocyte subpopulations by the enzymatic marker 20-alpha-hydroxysteroid dehydrogenase: differential responses to IL-1 and IL-2.

Authors:  E Aflalo; R Ofir; R N Apte; Y Weinstein
Journal:  Clin Exp Immunol       Date:  1987-12       Impact factor: 4.330
  1 in total

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