Literature DB >> 3486726

Exocrine pancreatic function as determined in a same-day test with use of bentiromide and p-aminosalicylic acid.

J D Berg, I M Chesner, R A Allen-Narker, B M Buckley, N Lawson.   

Abstract

We describe a new approach to the bentiromide test of exocrine pancreatic function, p-Aminosalicylic acid (PAS), a compound closely related to the bentiromide fragment p-aminobenzoic acid (PABA), is used as a marker of the pharmacokinetic behavior of PABA to derive a PABA excretion index. This index is identical to that derived with [14C]-PABA. Concentrations of both PABA and PAS are measured in urine by "high-performance" liquid chromatography, which avoids the drug interferences encountered with established assays of PABA. We discuss the practical and diagnostic advantages of this new approach to the bentiromide test.

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Year:  1986        PMID： 3486726

Source DB:  PubMed          Journal:  Clin Chem        ISSN： 0009-9147            Impact factor:   8.327


  6 in total

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  6 in total

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