Othmar Moser1,2, Christoph Sternad2, Max L Eckstein1, Agnieszka Szadkowska3, Arkadiusz Michalak4, Julia K Mader5, Haris Ziko5, Hesham Elsayed5, Felix Aberer1,2, Agnes Sola-Gazagnes6, Etienne Larger6,7, Gian Poalo Fadini8, Benedetta Maria Bonora8, Daniela Bruttomesso8, Federico Boscari8, Guido Freckmann9, Stefan Pleus9, Sverre C Christiansen10,11, Harald Sourij2. 1. Division of Exercise Physiology and Metabolism, Institute of Sport Science, University of Bayreuth, Bayreuth, Germany. 2. Interdisciplinary Metabolic Medicine Trials Unit, Medical University of Graz, Graz. 3. Department of Pediatrics, Diabetology, Endocrinology & Nephrology, Medical University of Lodz, Łódź, Poland. 4. Department of Biostatistics and Translational Medicine, Medical University of Lodz, Łódź, Poland. 5. Division of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria. 6. Department of Diabetology, Cochin Hospital, APHP Centre-Université de Paris, Paris, France. 7. Université de Paris, Paris, France. 8. Department of Medicine, University of Padova, Padova, Italy. 9. Institut für Diabetes-Technologie, Forschungs- und Entwicklungsgesellschaft mbH an der Universität Ulm, Ulm, Germany. 10. Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway. 11. Department of Endocrinology, St. Olav's University Hospital, Trondheim, Norway.
Abstract
AIMS: To conduct a pooled analysis to assess the performance of intermittently scanned continuous glucose monitoring (isCGM) in association with the rate of change in sensor glucose in a cohort of children, adolescents, and adults with type 1 diabetes. MATERIAL AND METHODS: In this pooled analysis, isCGM system accuracy was assessed depending on the rate of change in sensor glucose. Clinical studies that have been investigating isCGM accuracy against blood glucose, accompanied with collection time points were included in this analysis. isCGM performance was assessed by means of median absolute relative difference (MedARD), Parkes error grid (PEG) and Bland-Altman plot analyses. RESULTS: Twelve studies comprising 311 participants were included, with a total of 15 837 paired measurements. The overall MedARD (interquartile range) was 12.7% (5.9-23.5) and MedARD differed significantly based on the rate of change in glucose (P < 0.001). An absolute difference of -22 mg/dL (-1.2 mmol/L) (95% limits of agreement [LoA] 60 mg/dL (3.3 mmol/L), -103 mg/dL (-5.7 mmol/L)) was found when glucose was rapidly increasing (isCGM glucose minus reference blood glucose), while a -32 mg/dL (1.8 mmol/L) (95% LoA 116 mg/dL (6.4 mmol/L), -51 mg/dL (-2.8 mmol/L)) absolute difference was observed in periods of rapidly decreasing glucose. CONCLUSIONS: The performance of isCGM was good when compared to reference blood glucose measurements. The rate of change in glucose for both increasing and decreasing glucose levels diminished isCGM performance, showing lower accuracy during high rates of glucose change.
AIMS: To conduct a pooled analysis to assess the performance of intermittently scanned continuous glucose monitoring (isCGM) in association with the rate of change in sensor glucose in a cohort of children, adolescents, and adults with type 1 diabetes. MATERIAL AND METHODS: In this pooled analysis, isCGM system accuracy was assessed depending on the rate of change in sensor glucose. Clinical studies that have been investigating isCGM accuracy against blood glucose, accompanied with collection time points were included in this analysis. isCGM performance was assessed by means of median absolute relative difference (MedARD), Parkes error grid (PEG) and Bland-Altman plot analyses. RESULTS: Twelve studies comprising 311 participants were included, with a total of 15 837 paired measurements. The overall MedARD (interquartile range) was 12.7% (5.9-23.5) and MedARD differed significantly based on the rate of change in glucose (P < 0.001). An absolute difference of -22 mg/dL (-1.2 mmol/L) (95% limits of agreement [LoA] 60 mg/dL (3.3 mmol/L), -103 mg/dL (-5.7 mmol/L)) was found when glucose was rapidly increasing (isCGM glucose minus reference blood glucose), while a -32 mg/dL (1.8 mmol/L) (95% LoA 116 mg/dL (6.4 mmol/L), -51 mg/dL (-2.8 mmol/L)) absolute difference was observed in periods of rapidly decreasing glucose. CONCLUSIONS: The performance of isCGM was good when compared to reference blood glucose measurements. The rate of change in glucose for both increasing and decreasing glucose levels diminished isCGM performance, showing lower accuracy during high rates of glucose change.
Authors: Janis R Schierbauer; Svenja Günther; Sandra Haupt; Rebecca T Zimmer; Beate E M Zunner; Paul Zimmermann; Nadine B Wachsmuth; Max L Eckstein; Felix Aberer; Harald Sourij; Othmar Moser Journal: Sensors (Basel) Date: 2022-04-19 Impact factor: 3.847
Authors: Zongqing Lu; Gan Tao; Xiaoyu Sun; Yijun Zhang; Mengke Jiang; Yu Liu; Meng Ling; Jin Zhang; Wenyan Xiao; Tianfeng Hua; Huaqing Zhu; Min Yang Journal: Front Public Health Date: 2022-04-29