| Literature DB >> 34864885 |
Nicoleta Siminea1, Victor Popescu2, Jose Angel Sanchez Martin3, Daniela Florea4, Georgiana Gavril4, Ana-Maria Gheorghe4, Corina Iţcuş5, Krishna Kanhaiya2, Octavian Pacioglu4, Laura Lona Popa6, Romica Trandafir7, Maria Iris Tusa8, Manuela Sidoroff8, Mihaela Păun9, Eugen Czeizler4, Andrei Păun10, Ion Petre11.
Abstract
To better understand the potential of drug repurposing in COVID-19, we analyzed control strategies over essential host factors for SARS-CoV-2 infection. We constructed comprehensive directed protein-protein interaction (PPI) networks integrating the top-ranked host factors, the drug target proteins and directed PPI data. We analyzed the networks to identify drug targets and combinations thereof that offer efficient control over the host factors. We validated our findings against clinical studies data and bioinformatics studies. Our method offers a new insight into the molecular details of the disease and into potentially new therapy targets for it. Our approach for drug repurposing is significant beyond COVID-19 and may be applied also to other diseases.Entities:
Keywords: COVID-19; drug repurposing; host factors; network biology; network controllability
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Year: 2022 PMID： 34864885 PMCID： PMC8690228 DOI： 10.1093/bib/bbab490
Source DB: PubMed Journal: Brief Bioinform ISSN： 1467-5463 Impact factor: 11.622