Karen W Yeh1, Di He2, Johnni Hansen3, Catherine L Carpenter4, Beate Ritz5, Jorn Olsen6, Julia E Heck7. 1. Department of Epidemiology, Fielding School of Public Health, University of California, 10833 Le Conte Ave, Los Angeles, CA 90095, USA. Electronic address: karenwyeh@g.ucla.edu. 2. Department of Epidemiology, Fielding School of Public Health, University of California, 10833 Le Conte Ave, Los Angeles, CA 90095, USA. Electronic address: dihe7@ucla.edu. 3. Danish Cancer Society Research Center, Strandboulevarden 49, 2100 Copenhagen, Denmark. Electronic address: johnni@cancer.dk. 4. Department of Epidemiology, Fielding School of Public Health, University of California, 10833 Le Conte Ave, Los Angeles, CA 90095, USA. Electronic address: ccarpenter@mednet.ucla.edu. 5. Department of Epidemiology, Fielding School of Public Health, University of California, 10833 Le Conte Ave, Los Angeles, CA 90095, USA. Electronic address: britz@ucla.edu. 6. Department of Clinical Epidemiology, Aarhus University, Olof Palmes Alle 43-45, 8200 Aarhus N Aarhus, Denmark. Electronic address: jo@ph.au.dk. 7. Department of Epidemiology, Fielding School of Public Health, University of California, 10833 Le Conte Ave, Los Angeles, CA 90095, USA; College of Health and Public Service, University of North Texas, 1155 Union Circle, Denton, TX, 76203, USA. Electronic address: julia.heck@unt.edu.
Abstract
BACKGROUND: Head trauma has been associated with increased brain tumor risk in adults. Instrument assisted delivery can be a cause of head trauma in newborns. The goal of this study was to determine if instrument-assisted deliveries influenced the odds of childhood brain tumors in Denmark. METHODS: We conducted a matched case-control study of childhood (<20 years) brain tumors in Denmark born between 1978 and 2013 and diagnosed 1978-2016. A total of 1678 brain tumor cases were identified and 25 controls were matched to each case based on the child's sex and birth date (N = 40,934). Conditional logistic regression was used to estimate effects (odds ratios (OR) and 95% confidence intervals (95%CI)) for variables of interest. RESULTS: Compared to children birthed by spontaneous vaginal delivery, children who later developed ependymomas (N = 118) had a greater likelihood of having experienced vacuum assisted deliveries (OR=1.74, 95% CI 1.02-2.96). Forceps use was low, and declined across the study period. We did not observe an overall increase in all CNS tumors (combined) with either vacuum delivery (OR=0.99, 95% CI 0.84-1.18) or forceps delivery (OR=1.26, 95% CI 0.78-2.03). CONCLUSION: Our findings suggest an association between vacuum assisted deliveries and ependymomas.
BACKGROUND: Head trauma has been associated with increased brain tumor risk in adults. Instrument assisted delivery can be a cause of head trauma in newborns. The goal of this study was to determine if instrument-assisted deliveries influenced the odds of childhood brain tumors in Denmark. METHODS: We conducted a matched case-control study of childhood (<20 years) brain tumors in Denmark born between 1978 and 2013 and diagnosed 1978-2016. A total of 1678 brain tumor cases were identified and 25 controls were matched to each case based on the child's sex and birth date (N = 40,934). Conditional logistic regression was used to estimate effects (odds ratios (OR) and 95% confidence intervals (95%CI)) for variables of interest. RESULTS: Compared to children birthed by spontaneous vaginal delivery, children who later developed ependymomas (N = 118) had a greater likelihood of having experienced vacuum assisted deliveries (OR=1.74, 95% CI 1.02-2.96). Forceps use was low, and declined across the study period. We did not observe an overall increase in all CNS tumors (combined) with either vacuum delivery (OR=0.99, 95% CI 0.84-1.18) or forceps delivery (OR=1.26, 95% CI 0.78-2.03). CONCLUSION: Our findings suggest an association between vacuum assisted deliveries and ependymomas.
Authors: M McCredie; J Little; S Cotton; B Mueller; R Peris-Bonet; N W Choi; S Cordier; G Filippini; E A Holly; B Modan; A Arslan; S Preston-Martin Journal: Paediatr Perinat Epidemiol Date: 1999-07 Impact factor: 3.980
Authors: Erin L Marcotte; Thomas P Thomopoulos; Claire Infante-Rivard; Jacqueline Clavel; Eleni Th Petridou; Joachim Schüz; Sameera Ezzat; John D Dockerty; Catherine Metayer; Corrado Magnani; Michael E Scheurer; Beth A Mueller; Ana M Mora; Catharina Wesseling; Alkistis Skalkidou; Wafaa M Rashed; Stephen S Francis; Roula Ajrouche; Friederike Erdmann; Laurent Orsi; Logan G Spector Journal: Lancet Haematol Date: 2016-02-27 Impact factor: 18.959
Authors: Aris T Papageorghiou; Eric O Ohuma; Douglas G Altman; Tullia Todros; Leila Cheikh Ismail; Ann Lambert; Yasmin A Jaffer; Enrico Bertino; Michael G Gravett; Manorama Purwar; J Alison Noble; Ruyan Pang; Cesar G Victora; Fernando C Barros; Maria Carvalho; Laurent J Salomon; Zulfiqar A Bhutta; Stephen H Kennedy; José Villar Journal: Lancet Date: 2014-09-06 Impact factor: 79.321
Authors: Cari M Kitahara; Martha S Linet; Alina V Brenner; Sophia S Wang; Beatrice S Melin; Zhaoming Wang; Peter D Inskip; Laura E Beane Freeman; Melissa Z Braganza; Tania Carreón; Maria Feychting; J Michael Gaziano; Ulrike Peters; Mark P Purdue; Avima M Ruder; Howard D Sesso; Xiao-Ou Shu; Martha A Waters; Emily White; Wei Zheng; Robert N Hoover; Joseph F Fraumeni; Nilanjan Chatterjee; Meredith Yeager; Stephen J Chanock; Patricia Hartge; Preetha Rajaraman Journal: Cancer Epidemiol Biomarkers Prev Date: 2013-11-12 Impact factor: 4.254