Literature DB >> 34863096

Adipose tissue macrophages in aging-associated adipose tissue function.

Bangchao Lu1, Liang Huang1, Juan Cao1, Lingling Li1, Wenhui Wu1, Xiaolin Chen1, Congzhu Ding2.   

Abstract

"Inflammaging" refers to the chronic, low-grade inflammation that characterizes aging. Aging, like obesity, is associated with visceral adiposity and insulin resistance. Adipose tissue macrophages (ATMs) have played a major role in obesity-associated inflammation and insulin resistance. Macrophages are elevated in adipose tissue in aging. However, the changes and also possibly functions of ATMs in aging and aging-related diseases are unclear. In this review, we will summarize recent advances in research on the role of adipose tissue macrophages with aging-associated insulin resistance and discuss their potential therapeutic targets for preventing and treating aging and aging-related diseases.
© 2021. The Author(s).

Entities:  

Keywords:  Adipose tissue macrophages; Age; Insulin resistance

Mesh：

Year:  2021        PMID： 34863096     DOI： 10.1186/s12576-021-00820-2

Source DB:  PubMed          Journal:  J Physiol Sci        ISSN： 1880-6546            Impact factor:   2.781


  60 in total

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2.  CCR2 modulates inflammatory and metabolic effects of high-fat feeding.

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3.  M2 macrophages in metabolism.

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Review 5.  Changes in adipose tissue cellular composition during obesity and aging as a cause of metabolic dysregulation.

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6.  Obesity is associated with macrophage accumulation in adipose tissue.

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7.  Dead adipocytes, detected as crown-like structures, are prevalent in visceral fat depots of genetically obese mice.

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10.  Relation of depot-specific adipose inflammation to insulin resistance in human obesity.

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