Literature DB >> 34862737

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Year:  2021        PMID: 34862737      PMCID: PMC8642674          DOI: 10.1111/jcmm.17050

Source DB:  PubMed          Journal:  J Cell Mol Med        ISSN: 1582-1838            Impact factor:   5.310


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In Gang Guo, the published version contains an error in the bottom left image in Figure 5D. The correct figure is shown below. All results and conclusions remain intact. The authors apologize for the errors.
FIGURE 5

Depleting IL‐6 in myeloid cells decreases toxin‐induced liver damage in mice. (A) Schematic representation of the experimental design. The inserted H&E‐stained tissue sections show the deconstructed (upper) and reconstructed bone marrow (lower). (B) H&E staining of the liver tissue shows improved hepatic histology was observed in the mice with IL‐6–deficient bone marrow. The necrotic zones are circled with black dotted lines. (C) Biochemical assays of hepatic indexes; n = 6. (D) Macrophage aggregation in the liver as indicated by immunohistochemical staining for F4/80. (E) Flow cytometric analysis of the activated monocytes (CD11b+CD16+CCR2+) in the peripheral blood monocyte subsets; n = 4. (F) Circulating factors were suppressed in the mice that received IL‐6–deficient bone marrow after toxin challenge; n = 6. All the data represent the means ± SEM; *P < 0.05, ***P < 0.001

Depleting IL‐6 in myeloid cells decreases toxin‐induced liver damage in mice. (A) Schematic representation of the experimental design. The inserted H&E‐stained tissue sections show the deconstructed (upper) and reconstructed bone marrow (lower). (B) H&E staining of the liver tissue shows improved hepatic histology was observed in the mice with IL‐6–deficient bone marrow. The necrotic zones are circled with black dotted lines. (C) Biochemical assays of hepatic indexes; n = 6. (D) Macrophage aggregation in the liver as indicated by immunohistochemical staining for F4/80. (E) Flow cytometric analysis of the activated monocytes (CD11b+CD16+CCR2+) in the peripheral blood monocyte subsets; n = 4. (F) Circulating factors were suppressed in the mice that received IL‐6–deficient bone marrow after toxin challenge; n = 6. All the data represent the means ± SEM; *P < 0.05, ***P < 0.001
  1 in total

1.  Circulating monocytes accelerate acute liver failure by IL-6 secretion in monkey.

Authors:  Gang Guo; Yongjie Zhu; Zhenru Wu; Hongjie Ji; Xufeng Lu; Yongjie Zhou; Yuanmin Li; Xiaoyue Cao; Yanrong Lu; Prue Talbot; Jiayu Liao; Yujun Shi; Hong Bu
Journal:  J Cell Mol Med       Date:  2018-07-11       Impact factor: 5.310

  1 in total

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