Literature DB >> 34862229

Not always as simple as a UTI: An atypical case of Lemierre's syndrome, the forgotten disease.

Diviyesh Panchani1, Deepak Nair2.   

Abstract

A 65-year-old man, who was previously fit and well with no known medical comorbidities, was admitted with symptoms of dysuria, urinary frequency, pyrexia, chills and lethargy. His vitals showed that he was hypotensive, tachycardic and pyrexial. Urine dip was heavily positive for leukocytes and nitrites and had markedly elevated inflammatory markers and mild acute kidney injury. He was commenced on piperacillin/tazobactam. He went on to develop severe left-sided neck swelling and erythema. Ultrasound of the neck with subsequent computed tomography revealed extensive internal jugular vein thrombosis with abscess collection around the vein. Microbiology grew Gram-negative bacilli, later identified as Fusobacterium necrophorum A diagnosis of Lemierre's syndrome was made. The patient was continued on intravenous piperacillin/tazobactam and metronidazole as per sensitivities and later switched to oral metronidazole. He was initiated on warfarin anticoagulation. He made a remarkable recovery and was discharged with outpatient ear, nose and throat and haematology follow-up. © Royal College of Physicians 2021. All rights reserved.

Entities:  

Keywords:  Fusobacterium; Lemierre's syndrome; necrobacillosis; septic thrombophlebitis; the forgotten disease

Mesh:

Substances:

Year:  2021        PMID: 34862229      PMCID: PMC8806302          DOI: 10.7861/clinmed.2021-0579

Source DB:  PubMed          Journal:  Clin Med (Lond)        ISSN: 1470-2118            Impact factor:   2.659


  6 in total

Review 1.  Lemierre's syndrome (necrobacillosis).

Authors:  R Golpe; B Marín; M Alonso
Journal:  Postgrad Med J       Date:  1999-03       Impact factor: 2.401

Review 2.  The Lemierre syndrome: suppurative thrombophlebitis of the internal jugular vein secondary to oropharyngeal infection.

Authors:  C P Sinave; G J Hardy; P W Fardy
Journal:  Medicine (Baltimore)       Date:  1989-03       Impact factor: 1.889

Review 3.  Fusobacterium necrophorum infections: virulence factors, pathogenic mechanism and control measures.

Authors:  Z L Tan; T G Nagaraja; M M Chengappa
Journal:  Vet Res Commun       Date:  1996       Impact factor: 2.459

4.  Fusobacterium necrophorum sepsis after tonsillitis/pharyngitis.

Authors:  Micheal Sheehan; Darren McLoughlin; Ronan O'Sullivan
Journal:  BMJ Case Rep       Date:  2019-01-29

5.  Lemierre syndrome secondary to community-acquired methicillin-resistant Staphylococcus aureus infection associated with cavernous sinus thromboses.

Authors:  Craig Stauffer; Anne F Josiah; Manuel Fortes; Jay Menaker; John W Cole
Journal:  J Emerg Med       Date:  2012-09-16       Impact factor: 1.484

6.  Lemierre's syndrome.

Authors:  Wesley Eilbert; Nitin Singla
Journal:  Int J Emerg Med       Date:  2013-10-23
  6 in total

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