Dixon Yang1, Cen Zhang2, Setareh S Omran3, Brett Cucchiara4, Tatjana Rundek5, Clinton B Wright6, Ralph L Sacco5, Mitchell S V Elkind7, Jose Gutierrez8. 1. Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, United States of America. 2. Department of Neurology, New York University Grossman School of Medicine, New York, NY, United States of America. 3. Department of Neurology, University of Colorado School of Medicine, Aurora, CO, United States of America. 4. Department of Neurology, University of Pennsylvania, Philadelphia, PA, United States of America. 5. Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, United States of America. 6. National Institute of Neurologic Disorders and Stroke, Bethesda, MD, United States of America. 7. Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, United States of America; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, United States of America. 8. Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, United States of America. Electronic address: jg3233@cumc.columbia.edu.
Abstract
INTRODUCTION: Genetic and imaging studies demonstrate a link between vascular morphology and migraine with aura (MA). We examined the relationship between basilar artery (BA) curvature and MA in a population-based cohort of stroke-free participants. METHODS: This cross-sectional study included participants from the MRI substudy of the Northern Manhattan Study. Participants had structured migraine assessments at enrollment and underwent brain MR angiography. BA curvature was defined as the sum of the total BA horizontal deviation from midline at the distal tip, mid-pons, and vertebrobasilar junction, and was the primary independent variable in logistic regression analyses. BA measurements were obtained blinded to migraine status. We compared groups of all migraine vs no migraine, migraine without aura (MwoA) vs no migraine, and MA vs no migraine. RESULTS: Of 880 participants, 146 had MwoA and 32 had MA. Average BA curvatures were 15.2 ± 8.9 mm in non-migraineurs, 15.8 ± 9.3 mm in MwoA, and 18.5 ± 11.4 mm in MA. In an adjusted model, greater BA curvature was associated with MA (OR 1.042 per mm, 95% CI 1.006-1.080) but not with MwoA (OR 1.014 per mm, 95% CI 0.993-1.035), when compared to non-migraineurs. CONCLUSIONS: Greater BA curvature was associated with MA. Given aura typically originates from the occipital cortex, understanding the physiopathology of this association may provide clues to migraine's underlying mechanisms and relationship with stroke.
INTRODUCTION: Genetic and imaging studies demonstrate a link between vascular morphology and migraine with aura (MA). We examined the relationship between basilar artery (BA) curvature and MA in a population-based cohort of stroke-free participants. METHODS: This cross-sectional study included participants from the MRI substudy of the Northern Manhattan Study. Participants had structured migraine assessments at enrollment and underwent brain MR angiography. BA curvature was defined as the sum of the total BA horizontal deviation from midline at the distal tip, mid-pons, and vertebrobasilar junction, and was the primary independent variable in logistic regression analyses. BA measurements were obtained blinded to migraine status. We compared groups of all migraine vs no migraine, migraine without aura (MwoA) vs no migraine, and MA vs no migraine. RESULTS: Of 880 participants, 146 had MwoA and 32 had MA. Average BA curvatures were 15.2 ± 8.9 mm in non-migraineurs, 15.8 ± 9.3 mm in MwoA, and 18.5 ± 11.4 mm in MA. In an adjusted model, greater BA curvature was associated with MA (OR 1.042 per mm, 95% CI 1.006-1.080) but not with MwoA (OR 1.014 per mm, 95% CI 0.993-1.035), when compared to non-migraineurs. CONCLUSIONS: Greater BA curvature was associated with MA. Given aura typically originates from the occipital cortex, understanding the physiopathology of this association may provide clues to migraine's underlying mechanisms and relationship with stroke.
Authors: Ala Nozari; Ergin Dilekoz; Inna Sukhotinsky; Thor Stein; Katharina Eikermann-Haerter; Christina Liu; Yumei Wang; Matthew P Frosch; Christian Waeber; Cenk Ayata; Michael A Moskowitz Journal: Ann Neurol Date: 2010-02 Impact factor: 10.422
Authors: N Hadjikhani; M Sanchez Del Rio; O Wu; D Schwartz; D Bakker; B Fischl; K K Kwong; F M Cutrer; B R Rosen; R B Tootell; A G Sorensen; M A Moskowitz Journal: Proc Natl Acad Sci U S A Date: 2001-04-03 Impact factor: 11.205
Authors: Michelle L Rogers; Chi Leng Leong; Sally An Gowers; Isabelle C Samper; Sharon L Jewell; Asma Khan; Leanne McCarthy; Clemens Pahl; Christos M Tolias; Daniel C Walsh; Anthony J Strong; Martyn G Boutelle Journal: J Cereb Blood Flow Metab Date: 2016-01-01 Impact factor: 6.200