Ziling Mao1, Roberd M Bostick2,3. 1. Department of Epidemiology, Rollins School of Public Health, Emory University, Mailstop 1518-002-3BB, 1518 Clifton Road NE, Atlanta, GA, 30322, USA. 2. Department of Epidemiology, Rollins School of Public Health, Emory University, Mailstop 1518-002-3BB, 1518 Clifton Road NE, Atlanta, GA, 30322, USA. rmbosti@emory.edu. 3. Winship Cancer Institute, Emory University, Atlanta, GA, USA. rmbosti@emory.edu.
Abstract
PURPOSE: Plasma F2-isoprostanes (FiP) concentration, a reliably measured, valid, systemic oxidative stress biomarker, has been associated with multiple health-related outcomes; however, associations of most individual dietary and lifestyle exposures with FiP are unclear, and there is no reported oxidative balance score (OBS) comprising multiple dietary and/or lifestyle components weighted by their associations with FiP. METHODS: To investigate cross-sectional associations of dietary and lifestyle characteristics with plasma FiP concentrations, we used multivariable general linear models to compare adjusted mean FiP concentrations across categories of dietary nutrient and whole-food intakes and lifestyle characteristics in two pooled cross-sectional studies (n = 386). We also developed equal-weight and weighted OBS (nutrient- and foods-based dietary OBS, lifestyle OBS, and total OBS), and compared adjusted mean FiP concentrations across OBS tertiles. RESULTS: Among men and women combined, adjusted mean FiP concentrations were statistically significantly, proportionately 28.1% higher among those who were obese relative to those who were normal weight; among those in the highest relative to the lowest total nutrient intake tertiles, FiP concentrations were statistically significantly lower by 9.8% for carotenes, 13.6% for lutein/zeaxanthin, 10.9% for vitamin C, 12.2% for vitamin E, 11.5% for glucosinolates, and 5% for calcium. Of the various OBS, the weighted OBS that combined total nutrient intakes and lifestyle exposures was most strongly associated with FiP concentrations: among those in the highest relative to the lowest total OBS, mean FiP concentrations were statistically significantly 29.7% lower (P < 0.001). CONCLUSION: Multiple dietary and lifestyle characteristics, individually, and especially collectively, may contribute to systemic oxidative stress.
PURPOSE: Plasma F2-isoprostanes (FiP) concentration, a reliably measured, valid, systemic oxidative stress biomarker, has been associated with multiple health-related outcomes; however, associations of most individual dietary and lifestyle exposures with FiP are unclear, and there is no reported oxidative balance score (OBS) comprising multiple dietary and/or lifestyle components weighted by their associations with FiP. METHODS: To investigate cross-sectional associations of dietary and lifestyle characteristics with plasma FiP concentrations, we used multivariable general linear models to compare adjusted mean FiP concentrations across categories of dietary nutrient and whole-food intakes and lifestyle characteristics in two pooled cross-sectional studies (n = 386). We also developed equal-weight and weighted OBS (nutrient- and foods-based dietary OBS, lifestyle OBS, and total OBS), and compared adjusted mean FiP concentrations across OBS tertiles. RESULTS: Among men and women combined, adjusted mean FiP concentrations were statistically significantly, proportionately 28.1% higher among those who were obese relative to those who were normal weight; among those in the highest relative to the lowest total nutrient intake tertiles, FiP concentrations were statistically significantly lower by 9.8% for carotenes, 13.6% for lutein/zeaxanthin, 10.9% for vitamin C, 12.2% for vitamin E, 11.5% for glucosinolates, and 5% for calcium. Of the various OBS, the weighted OBS that combined total nutrient intakes and lifestyle exposures was most strongly associated with FiP concentrations: among those in the highest relative to the lowest total OBS, mean FiP concentrations were statistically significantly 29.7% lower (P < 0.001). CONCLUSION: Multiple dietary and lifestyle characteristics, individually, and especially collectively, may contribute to systemic oxidative stress.
Authors: J D Morrow; W E Zackert; J P Yang; E H Kurhts; D Callewaert; R Dworski; K Kanai; D Taber; K Moore; J A Oates; L J Roberts Journal: Anal Biochem Date: 1999-05-01 Impact factor: 3.365
Authors: Ben Schöttker; Kai-Uwe Saum; Eugène H J M Jansen; Paolo Boffetta; Antonia Trichopoulou; Bernd Holleczek; Aida Karina Dieffenbach; Hermann Brenner Journal: J Gerontol A Biol Sci Med Sci Date: 2014-07-28 Impact factor: 6.053
Authors: Ben Schöttker; Hermann Brenner; Eugène H J M Jansen; Julian Gardiner; Anne Peasey; Růžena Kubínová; Andrzej Pająk; Roman Topor-Madry; Abdonas Tamosiunas; Kai-Uwe Saum; Bernd Holleczek; Hynek Pikhart; Martin Bobak Journal: BMC Med Date: 2015-12-15 Impact factor: 8.775