Literature DB >> 3485960

Stimulation of wound healing by epidermal growth factor. A dose-dependent effect.

M Laato, J Niinikoski, L Lebel, B Gerdin.   

Abstract

This work was undertaken to study the effects of various doses of locally applied epidermal growth factor (EGF) on developing granulation tissue in rats. Cylindrical hollow sponge implants were used as an inductive matrix for the growth of granulation tissue. In the test groups, the implants were injected daily with a solution containing 0.2, 1, or 5 micrograms of EGF in 0.1% albumin while the implants of the control group were treated correspondingly with the carrier solution only. Analyses of granulation tissue in the sponge cylinders were carried out 7 days after implantation. A stimulatory, dose-dependent effect of EGF on granulation tissue formation was observed: cellularity increased, as evidenced by the elevated amounts of nucleic acids, and accumulation of collagen and glycosaminoglycans was enhanced.

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Year:  1986        PMID： 3485960      PMCID： PMC1251121          DOI： 10.1097/00000658-198604000-00007

Source DB:  PubMed          Journal:  Ann Surg        ISSN： 0003-4932            Impact factor:   12.969


  15 in total

1.  Determination of nucleic acids in animal tissues.

Authors:  G CERIOTTI
Journal:  J Biol Chem       Date:  1955-05       Impact factor: 5.157

2.  A modified uronic acid carbazole reaction.

Authors:  T BITTER; H M MUIR
Journal:  Anal Biochem       Date:  1962-10       Impact factor: 3.365

3.  Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal.

Authors:  S COHEN
Journal:  J Biol Chem       Date:  1962-05       Impact factor: 5.157

4.  The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid.

Authors:  J F WOESSNER
Journal:  Arch Biochem Biophys       Date:  1961-05       Impact factor: 4.013

5.  A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid.

Authors:  K BURTON
Journal:  Biochem J       Date:  1956-02       Impact factor: 3.857

6.  Method for the determination of hexosamines in tissues.

Authors:  N F BOAS
Journal:  J Biol Chem       Date:  1953-10       Impact factor: 5.157

Review 7.  Epidermal growth factor-urogastrone, a polypeptide acquiring hormonal status.

Authors:  M D Hollenberg
Journal:  Vitam Horm       Date:  1979       Impact factor: 3.421

8.  Effects of topical applications of epidermal growth factor on wound healing. Experimental study on rabbit ears.

Authors:  J D Franklin; J B Lynch
Journal:  Plast Reconstr Surg       Date:  1979-12       Impact factor: 4.730

9.  The effect of epidermal growth factor on wound healing in mice.

Authors:  M Niall; G B Ryan; B M O'Brien
Journal:  J Surg Res       Date:  1982-08       Impact factor: 2.192

10.  Chemical synthesis of a gene for human epidermal growth factor urogastrone and its expression in yeast.

Authors:  M S Urdea; J P Merryweather; G T Mullenbach; D Coit; U Heberlein; P Valenzuela; P J Barr
Journal:  Proc Natl Acad Sci U S A       Date:  1983-12       Impact factor: 11.205
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  13 in total

1.  Growth regulation of skin cells by epidermal cell-derived factors: implications for wound healing.

Authors:  M Eisinger; S Sadan; I A Silver; R B Flick
Journal:  Proc Natl Acad Sci U S A       Date:  1988-03       Impact factor: 11.205

2.  Interleukin 1 modulates collagen accumulation by rat granulation tissue cells both in vivo and in vitro.

Authors:  M Laato; J Heino
Journal:  Experientia       Date:  1988-01-15

3.  Effect of cell-cell and cell-matrix interactions on the response of fibroblasts to epidermal growth factor in vitro. Expression of collagen type I, collagenase, stromelysin and tissue inhibitor of metalloproteinases.

Authors:  A C Colige; C A Lambert; B V Nusgens; C M Lapière
Journal:  Biochem J       Date:  1992-07-01       Impact factor: 3.857

4.  The effect of epidermal growth factor applied locally for pelviureteral anastomoses.

Authors:  Müslim Yurtçu; Zeliha Füsun Baba
Journal:  Int J Clin Exp Med       Date:  2014-11-15

5.  Improvement in wound healing by epidermal growth factor (EGF) ointment. I. Effect of nafamostat, gabexate, or gelatin on stabilization and efficacy of EGF.

Authors:  K Okumura; Y Kiyohara; F Komada; S Iwakawa; M Hirai; T Fuwa
Journal:  Pharm Res       Date:  1990-12       Impact factor: 4.200

6.  Effects of longterm epidermal growth factor treatment on the normal rat colon.

Authors:  P Kissmeyer-Nielsen; L Vinter-Jensen; M Smerup
Journal:  Gut       Date:  1996-04       Impact factor: 23.059

7.  Evaluation of the release rate of bioactive recombinant human epidermal growth factor from crosslinking collagen sponges.

Authors:  Chih-Hui Yang
Journal:  J Mater Sci Mater Med       Date:  2007-10-04       Impact factor: 3.896

8.  Epidermal growth factor increases collagen production in granulation tissue by stimulation of fibroblast proliferation and not by activation of procollagen genes.

Authors:  M Laato; V M Kähäri; J Niinikoski; E Vuorio
Journal:  Biochem J       Date:  1987-10-15       Impact factor: 3.857

9.  Epidermal growth factor-containing wound closure enhances wound healing in non-diabetic and diabetic rats.

Authors:  S Dogan; S Demirer; I Kepenekci; B Erkek; A Kiziltay; N Hasirci; S Müftüoglu; A Nazikoglu; N Renda; U D Dincer; A Elhan; E Kuterdem
Journal:  Int Wound J       Date:  2009-04       Impact factor: 3.315

10.  Transforming growth factor-alpha is a constant component of human tear fluid.

Authors:  G van Setten; G Schultz
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1994-09       Impact factor: 3.117
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