Literature DB >> 34859148

How multi-component cascades operate in cells: lessons from the ubiquitin system-containing liquid-separated condensates.

Afu Fu1, Ido Livneh1, Aaron Ciechanover1, Victoria Cohen-Kaplan1.   

Abstract

Membraneless condensates have recently caught the attention of biologists as hubs for cellular components required for catalysis of basic processes. Whether they are real has become the center of heated discussion where the main issues are their mechanism of assembly and function. A recent study describing these condensates as hubs for protein degradation by the ubiquitin system may shed a new light on this recent development in cell biology.
© 2021 Taylor & Francis Group, LLC.

Entities:  

Keywords:  LLPS condensates; p62; proteasome; protein degradation; ubiquitin

Year:  2021        PMID： 34859148      PMCID： PMC8632267          DOI： 10.1080/23723556.2021.1989939

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

Review 1.  The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction.

Authors:  Michael H Glickman; Aaron Ciechanover
Journal:  Physiol Rev       Date:  2002-04       Impact factor: 37.312

2.  Diverse fate of ubiquitin chain moieties: The proximal is degraded with the target, and the distal protects the proximal from removal and recycles.

Authors:  Hao Sun; Sachitanand M Mali; Sumeet K Singh; Roman Meledin; Ashraf Brik; Yong Tae Kwon; Yelena Kravtsova-Ivantsiv; Beatrice Bercovich; Aaron Ciechanover
Journal:  Proc Natl Acad Sci U S A       Date:  2019-03-13       Impact factor: 11.205

3.  Designer membraneless organelles enable codon reassignment of selected mRNAs in eukaryotes.

Authors:  Christopher D Reinkemeier; Gemma Estrada Girona; Edward A Lemke
Journal:  Science       Date:  2019-03-29       Impact factor: 47.728

Review 4.  The ubiquitin-proteasome system and autophagy: Coordinated and independent activities.

Authors:  Victoria Cohen-Kaplan; Ido Livneh; Noa Avni; Chen Cohen-Rosenzweig; Aaron Ciechanover
Journal:  Int J Biochem Cell Biol       Date:  2016-07-20       Impact factor: 5.085

Review 5.  Chaperone-mediated autophagy and endosomal microautophagy: Joint by a chaperone.

Authors:  Kumsal Tekirdag; Ana Maria Cuervo
Journal:  J Biol Chem       Date:  2017-12-15       Impact factor: 5.157

6.  p62- and ubiquitin-dependent stress-induced autophagy of the mammalian 26S proteasome.

Authors:  Victoria Cohen-Kaplan; Ido Livneh; Noa Avni; Bertrand Fabre; Tamar Ziv; Yong Tae Kwon; Aaron Ciechanover
Journal:  Proc Natl Acad Sci U S A       Date:  2016-10-17       Impact factor: 11.205

7.  Stress- and ubiquitylation-dependent phase separation of the proteasome.

Authors:  Sayaka Yasuda; Hikaru Tsuchiya; Ai Kaiho; Qiang Guo; Ken Ikeuchi; Akinori Endo; Naoko Arai; Fumiaki Ohtake; Shigeo Murata; Toshifumi Inada; Wolfgang Baumeister; Rubén Fernández-Busnadiego; Keiji Tanaka; Yasushi Saeki
Journal:  Nature       Date:  2020-02-05       Impact factor: 49.962

8.  p62-containing, proteolytically active nuclear condensates, increase the efficiency of the ubiquitin-proteasome system.

Authors:  Afu Fu; Victoria Cohen-Kaplan; Noa Avni; Ido Livneh; Aaron Ciechanover
Journal:  Proc Natl Acad Sci U S A       Date:  2021-08-17       Impact factor: 11.205

9.  Intracellular localization of proteasomal degradation of a viral antigen.

Authors:  L C Antón; U Schubert; I Bacík; M F Princiotta; P A Wearsch; J Gibbs; P M Day; C Realini; M C Rechsteiner; J R Bennink; J W Yewdell
Journal:  J Cell Biol       Date:  1999-07-12       Impact factor: 10.539

Review 10.  Evaluating phase separation in live cells: diagnosis, caveats, and functional consequences.

Authors:  David T McSwiggen; Mustafa Mir; Xavier Darzacq; Robert Tjian
Journal:  Genes Dev       Date:  2019-10-08       Impact factor: 11.361
  10 in total

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