Literature DB >> 34859144

Mitochondrial homeostasis is maintained in the absence of autophagy.

Christina G Towers1.   

Abstract

Autophagy is a central recycling process, and it plays a complex role in cancer. We discovered that when autophagy is blocked, cancer cells compensate by increasing mitochondrial-derived vesicles. However, there are many unanswered questions remaining, particularly in the context of the dual roles of autophagy in cancer.
© 2021 Taylor & Francis Group, LLC.

Entities:  

Keywords:  Autophagy; cancer; mitochondria; mitochondrial derived vesicles; mitophagy

Year:  2021        PMID： 34859144      PMCID： PMC8632333          DOI： 10.1080/23723556.2021.1984162

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  Autophagy-dependent cancer cells circumvent loss of the upstream regulator RB1CC1/FIP200 and loss of LC3 conjugation by similar mechanisms.

Authors:  Christina G Towers; Darya Wodetzki; Andrew Thorburn
Journal:  Autophagy       Date:  2020-03-18       Impact factor: 16.016

Review 2.  Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance.

Authors:  Sarah Pickles; Pierre Vigié; Richard J Youle
Journal:  Curr Biol       Date:  2018-02-19       Impact factor: 10.834

3.  A vesicular transport pathway shuttles cargo from mitochondria to lysosomes.

Authors:  Vincent Soubannier; Gian-Luca McLelland; Rodolfo Zunino; Emelie Braschi; Peter Rippstein; Edward A Fon; Heidi M McBride
Journal:  Curr Biol       Date:  2012-01-05       Impact factor: 10.834

Review 4.  Targeting Autophagy in Cancer: Recent Advances and Future Directions.

Authors:  Ravi K Amaravadi; Alec C Kimmelman; Jayanta Debnath
Journal:  Cancer Discov       Date:  2019-08-21       Impact factor: 39.397

5.  Cancer Cells Upregulate NRF2 Signaling to Adapt to Autophagy Inhibition.

Authors:  Christina G Towers; Brent E Fitzwalter; Daniel Regan; Andrew Goodspeed; Michael J Morgan; Chang-Wei Liu; Daniel L Gustafson; Andrew Thorburn
Journal:  Dev Cell       Date:  2019-08-01       Impact factor: 12.270

Review 6.  Mitochondria and Cancer.

Authors:  Wei-Xing Zong; Joshua D Rabinowitz; Eileen White
Journal:  Mol Cell       Date:  2016-03-03       Impact factor: 17.970

Review 7.  Mechanism and medical implications of mammalian autophagy.

Authors:  Ivan Dikic; Zvulun Elazar
Journal:  Nat Rev Mol Cell Biol       Date:  2018-06       Impact factor: 94.444

Review 8.  Autophagy, Metabolism, and Cancer.

Authors:  Jessie Yanxiang Guo; Eileen White
Journal:  Cold Spring Harb Symp Quant Biol       Date:  2017-02-16

9.  Mitochondrial-derived vesicles compensate for loss of LC3-mediated mitophagy.

Authors:  Christina G Towers; Darya K Wodetzki; Jacqueline Thorburn; Katharine R Smith; M Cecilia Caino; Andrew Thorburn
Journal:  Dev Cell       Date:  2021-06-24       Impact factor: 13.417

10.  Autophagy and cancer: Modulation of cell death pathways and cancer cell adaptations.

Authors:  Christina G Towers; Darya Wodetzki; Andrew Thorburn
Journal:  J Cell Biol       Date:  2020-01-06       Impact factor: 10.539
  10 in total

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