Literature DB >> 34859142

From mouse genetics to targeting the Rag GTPase pathway.

Ana Ortega-Molina1, Alejo Efeyan1.   

Abstract

The identification of the Rag GTPases initiated the deciphering of the molecular puzzle of nutrient signaling to the mechanistic target of rapamycin (mTOR), and spurred interest in targeting this pathway to combat human disease. Recent mouse genetic studies have provided pathophysiological insight and pointed to potential indications for inhibitors of the Rag GTPase pathway.
© 2021 Taylor & Francis Group, LLC.

Entities:  

Keywords:  B cells; Mtor; Rag GTPases; nutrients; lymphoma; mice; small molecules

Year:  2021        PMID： 34859142      PMCID： PMC8632321          DOI： 10.1080/23723556.2021.1979370

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  11 in total

1.  Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase.

Authors:  Jonatan Ersching; Alejo Efeyan; Luka Mesin; Johanne T Jacobsen; Giulia Pasqual; Brian C Grabiner; David Dominguez-Sola; David M Sabatini; Gabriel D Victora
Journal:  Immunity       Date:  2017-06-20       Impact factor: 31.745

2.  RagA, but not RagB, is essential for embryonic development and adult mice.

Authors:  Alejo Efeyan; Lawrence D Schweitzer; Angelina M Bilate; Steven Chang; Oktay Kirak; Dudley W Lamming; David M Sabatini
Journal:  Dev Cell       Date:  2014-04-24       Impact factor: 12.270

3.  Follicular lymphoma genomics.

Authors:  Lucy Pickard; Giuseppe Palladino; Jessica Okosun
Journal:  Leuk Lymphoma       Date:  2020-05-19

4.  Oncogenic Rag GTPase signaling enhances B cell activation and drives follicular lymphoma sensitive to pharmacological inhibition of mTOR.

Authors:  Ana Ortega-Molina; Nerea Deleyto-Seldas; Joaquim Carreras; Alba Sanz; Cristina Lebrero-Fernández; Camino Menéndez; Andrew Vandenberg; Beatriz Fernández-Ruiz; Leyre Marín-Arraiza; Celia de la Calle Arregui; Ana Belén Plata-Gómez; Eduardo Caleiras; Alba de Martino; Nuria Martínez-Martín; Kevin Troulé; Elena Piñeiro-Yáñez; Naoya Nakamura; Shamzah Araf; Gabriel D Victora; Jessica Okosun; Jude Fitzgibbon; Alejo Efeyan
Journal:  Nat Metab       Date:  2019-08-19

5.  Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival.

Authors:  Alejo Efeyan; Roberto Zoncu; Steven Chang; Iwona Gumper; Harriet Snitkin; Rachel L Wolfson; Oktay Kirak; David D Sabatini; David M Sabatini
Journal:  Nature       Date:  2012-12-23       Impact factor: 49.962

Review 6.  Molecular logic of mTORC1 signalling as a metabolic rheostat.

Authors:  Alexander J Valvezan; Brendan D Manning
Journal:  Nat Metab       Date:  2019-03-04

7.  Rag GTPases are cardioprotective by regulating lysosomal function.

Authors:  Hyun Woo Park; Sebastiano Sciarretta; Young Chul Kim; Jung-Soon Mo; Jenna L Jewell; Ryan C Russell; Xiaohui Wu; Junichi Sadoshima; Kun-Liang Guan
Journal:  Nat Commun       Date:  2014-07-01       Impact factor: 14.919

8.  Limited survival and impaired hepatic fasting metabolism in mice with constitutive Rag GTPase signaling.

Authors:  Celia de la Calle Arregui; Ana Belén Plata-Gómez; Nerea Deleyto-Seldas; Fernando García; Ana Ortega-Molina; Julio Abril-Garrido; Elena Rodriguez; Ivan Nemazanyy; Laura Tribouillard; Alba de Martino; Eduardo Caleiras; Ramón Campos-Olivas; Francisca Mulero; Mathieu Laplante; Javier Muñoz; Mario Pende; Guadalupe Sabio; David M Sabatini; Alejo Efeyan
Journal:  Nat Commun       Date:  2021-06-16       Impact factor: 14.919

Review 9.  The mTOR-Autophagy Axis and the Control of Metabolism.

Authors:  Nerea Deleyto-Seldas; Alejo Efeyan
Journal:  Front Cell Dev Biol       Date:  2021-07-01

10.  Inhibition of Rag GTPase signaling in mice suppresses B cell responses and lymphomagenesis with minimal detrimental trade-offs.

Authors:  Ana Ortega-Molina; Cristina Lebrero-Fernández; Alba Sanz; Nerea Deleyto-Seldas; Ana Belén Plata-Gómez; Camino Menéndez; Osvaldo Graña-Castro; Eduardo Caleiras; Alejo Efeyan
Journal:  Cell Rep       Date:  2021-07-13       Impact factor: 9.423
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