Literature DB >> 34859139

The roads to ferroptosis under homeostatic versus pathological conditions.

Vincent Chen1, Chu Bo1, Wei Gu1.   

Abstract

The calcium-independent phospholipase iPLA2β has been identified as a transcriptional target of the tumor suppressor TP53 (or p53). Unlike GPX4 (glutathione peroxidase 4), iPLA2β is not required for normal homeostasis but critical for ferroptosis during stress responses. Our results implicate iPLA2β as an essential regulator in a noncanonical ferroptosis pathway.
© 2021 Taylor & Francis Group, LLC.

Entities:  

Keywords:  Ferroptosis; iPLA2β; lipid peroxidation; p53

Year:  2021        PMID： 34859139      PMCID： PMC8632319          DOI： 10.1080/23723556.2021.1970477

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

Review 1.  Calcium-independent phospholipases A2 and their roles in biological processes and diseases.

Authors:  Sasanka Ramanadham; Tomader Ali; Jason W Ashley; Robert N Bone; William D Hancock; Xiaoyong Lei
Journal:  J Lipid Res       Date:  2015-05-28       Impact factor: 5.922

2.  Regulation of ferroptotic cancer cell death by GPX4.

Authors:  Wan Seok Yang; Rohitha SriRamaratnam; Matthew E Welsch; Kenichi Shimada; Rachid Skouta; Vasanthi S Viswanathan; Jaime H Cheah; Paul A Clemons; Alykhan F Shamji; Clary B Clish; Lewis M Brown; Albert W Girotti; Virginia W Cornish; Stuart L Schreiber; Brent R Stockwell
Journal:  Cell       Date:  2014-01-16       Impact factor: 41.582

3.  PLA2G6 guards placental trophoblasts against ferroptotic injury.

Authors:  Ofer Beharier; Vladimir A Tyurin; Julie P Goff; Jennifer Guerrero-Santoro; Kazuhiro Kajiwara; Tianjiao Chu; Yulia Y Tyurina; Claudette M St Croix; Callen T Wallace; Samuel Parry; W Tony Parks; Valerian E Kagan; Yoel Sadovsky
Journal:  Proc Natl Acad Sci U S A       Date:  2020-10-21       Impact factor: 11.205

Review 4.  Emerging Mechanisms and Disease Relevance of Ferroptosis.

Authors:  Brent R Stockwell; Xuejun Jiang; Wei Gu
Journal:  Trends Cell Biol       Date:  2020-03-21       Impact factor: 20.808

Review 5.  p53 and Tumor Suppression: It Takes a Network.

Authors:  Anthony M Boutelle; Laura D Attardi
Journal:  Trends Cell Biol       Date:  2021-01-28       Impact factor: 20.808

6.  Ferroptosis induces membrane blebbing in placental trophoblasts.

Authors:  Kazuhiro Kajiwara; Ofer Beharier; Choon-Peng Chng; Julie P Goff; Yingshi Ouyang; Claudette M St Croix; Changjin Huang; Valerian E Kagan; K Jimmy Hsia; Yoel Sadovsky
Journal:  J Cell Sci       Date:  2021-04-20       Impact factor: 5.285

7.  Phospholipase iPLA2β averts ferroptosis by eliminating a redox lipid death signal.

Authors:  Wan-Yang Sun; Vladimir A Tyurin; Karolina Mikulska-Ruminska; Indira H Shrivastava; Tamil S Anthonymuthu; Yu-Jia Zhai; Ming-Hai Pan; Hai-Biao Gong; Dan-Hua Lu; Jie Sun; Wen-Jun Duan; Sergey Korolev; Andrey Y Abramov; Plamena R Angelova; Ian Miller; Ofer Beharier; Gao-Wei Mao; Haider H Dar; Alexandr A Kapralov; Andrew A Amoscato; Teresa G Hastings; Timothy J Greenamyre; Charleen T Chu; Yoel Sadovsky; Ivet Bahar; Hülya Bayır; Yulia Y Tyurina; Rong-Rong He; Valerian E Kagan
Journal:  Nat Chem Biol       Date:  2021-02-04       Impact factor: 15.040

8.  The complexity of p53-mediated metabolic regulation in tumor suppression.

Authors:  Yanqing Liu; Wei Gu
Journal:  Semin Cancer Biol       Date:  2021-03-27       Impact factor: 17.012

9.  ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway.

Authors:  Bo Chu; Ning Kon; Delin Chen; Tongyuan Li; Tong Liu; Le Jiang; Shujuan Song; Omid Tavana; Wei Gu
Journal:  Nat Cell Biol       Date:  2019-04-08       Impact factor: 28.824

10.  iPLA2β-mediated lipid detoxification controls p53-driven ferroptosis independent of GPX4.

Authors:  Delin Chen; Bo Chu; Xin Yang; Zhaoqi Liu; Ying Jin; Ning Kon; Raul Rabadan; Xuejun Jiang; Brent R Stockwell; Wei Gu
Journal:  Nat Commun       Date:  2021-06-15       Impact factor: 14.919
  10 in total

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