Literature DB >> 3485895

Augmentation of thromboxane production in vitro by polymorphonuclears and macrophages exposed to IL1/LP.

P Conti, M G Cifone, E Alesse, C Fieschi, P U Angeletti.   

Abstract

Human peripheral blood polymorphonuclear leukocytes (PMNs) and murine peritoneal macrophages (M phi) were stimulated to generate thromboxane upon treatment with highly purified human interleukin 1/leukocytic pyrogen (IL1/LP) at various concentrations. Thromboxane B2 was measured by radioimmunoassay in the cell-free supernatants of cell suspensions after 1 hour incubation at 37 degrees C. Thromboxane B2 amounts increased in a way which depended on the dose of IL1 added to the cell cultures.

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Year:  1986        PMID： 3485895     DOI： 10.1007/BF01982659

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  2 in total

1.  Ability of human leukocytic pyrogen to stimulate brain prostaglandin synthesis in vitro.

Authors:  C A Dinarello; H A Bernheim
Journal:  J Neurochem       Date:  1981-09       Impact factor: 5.372

2.  Role of arachidonate metabolism in the immunoregulatory function of human leukocytic pyrogen/lymphocyte-activating factor/interleukin 1.

Authors:  C A Dinarello; S O Marnoy; L J Rosenwasser
Journal:  J Immunol       Date:  1983-02       Impact factor: 5.422
  2 in total
  5 in total

1.  Urinary thromboxane B2 as an indicator of acute rejection in human liver transplantation.

Authors:  H Isozaki; O Farges; D Samuel; R Adam; H Bismuth
Journal:  Surg Today       Date:  1996       Impact factor: 2.549

2.  Seventh European Rheumatology Research Workshop. Glasgow, Scotland, March 6-7, 1987. Abstracts.

Authors: 
Journal:  Clin Rheumatol       Date:  1987-03       Impact factor: 2.980

Review 3.  Secretory products of macrophages.

Authors:  C F Nathan
Journal:  J Clin Invest       Date:  1987-02       Impact factor: 14.808

4.  Human recombinant IL-1 receptor antagonist (IL-1Ra) inhibits leukotriene B4 generation from human monocyte suspensions stimulated by lipopolysaccharide (LPS).

Authors:  P Conti; M R Panara; R C Barbacane; M Bongrazio; R A Dempsey; M Reale
Journal:  Clin Exp Immunol       Date:  1993-03       Impact factor: 4.330

5.  The down-regulation of IL-6-stimulated fibrinogen steady state mRNA and protein levels by human recombinant IL-1 is not PGE2-dependent: effects of IL-1 receptor antagonist (IL-1RA).

Authors:  P Conti; L Bartle; R C Barbacane; M Reale; J D Sipe
Journal:  Mol Cell Biochem       Date:  1995-01-26       Impact factor: 3.396
  5 in total

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