Literature DB >> 3485683

Diabetic BioBreeding/Worcester (BB/Wor) rats need not be lymphopenic.

A A Like, D L Guberski, L Butler.   

Abstract

The BB/Wor rat is an animal model of spontaneous autoimmune type I diabetes mellitus. Previous reports have emphasized the presence of lymphopenia in all diabetic and diabetes-prone BB rats. This manuscript reports the appearance of diabetes among three family lines of BB/Wor animals that were previously free of diabetes. Diabetic W-line rats are not lymphopenic and possess normal percentages of phenotypic T cell subsets. Hence the presence of lymphopenia is not obligatory for the occurrence of diabetes in BB/Wor rats.

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Year:  1986        PMID： 3485683

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  16 in total

1.  Immunopathology of diabetes in the RT6-depleted diabetes-resistant BB/Wor rat.

Authors:  Z Jiang; E S Handler; A A Rossini; B A Woda
Journal:  Am J Pathol       Date:  1990-10       Impact factor: 4.307

2.  Adoptive transfer of autoimmune diabetes and thyroiditis to athymic rats.

Authors:  U McKeever; J P Mordes; D L Greiner; M C Appel; J Rozing; E S Handler; A A Rossini
Journal:  Proc Natl Acad Sci U S A       Date:  1990-10       Impact factor: 11.205

3.  Depletion of RT6.1+ T lymphocytes alone is insufficient to induce diabetes in diabetes-resistant BB/Wor rats.

Authors:  A A Like
Journal:  Am J Pathol       Date:  1990-03       Impact factor: 4.307

4.  Neonatal development of lymphoid organs and specific immune responses in situ in diabetes-prone BB rats.

Authors:  E P van Rees; H A Voorbij; C D Dijkstra
Journal:  Immunology       Date:  1988-11       Impact factor: 7.397

5.  Anti-CD2 monoclonal antibodies prevent spontaneous and adoptive transfer of diabetes in the BB/Wor rat.

Authors:  A K Barlow; A A Like
Journal:  Am J Pathol       Date:  1992-11       Impact factor: 4.307

Review 6.  Type 1 diabetes mellitus: an imbalance between effector and regulatory T cells?

Authors:  E J Rashba; E P Reich; C A Janeway; R S Sherwin
Journal:  Acta Diabetol       Date:  1993       Impact factor: 4.280

7.  BB-DR/Edinburgh: a lymphopenic, non-diabetic subline of BB rats.

Authors:  S Joseph; A G Diamond; W Smith; J D Baird; G W Butcher
Journal:  Immunology       Date:  1993-02       Impact factor: 7.397

8.  Identification of a limited T-cell receptor beta chain variable region repertoire associated with diabetes in the BB rat.

Authors:  D P Gold; D Bellgrau
Journal:  Proc Natl Acad Sci U S A       Date:  1991-11-01       Impact factor: 11.205

9.  Abnormal TNF production in prediabetic BB rats is linked to defective CD45R expression.

Authors:  H Rothe; I Schuller; G Richter; C V Jongeneel; U Kiesel; T Diamantstein; T Blankenstein; H Kolb
Journal:  Immunology       Date:  1992-09       Impact factor: 7.397

10.  Infection of peripancreatic lymph nodes but not islets precedes Kilham rat virus-induced diabetes in BB/Wor rats.

Authors:  D W Brown; R M Welsh; A A Like
Journal:  J Virol       Date:  1993-10       Impact factor: 5.103
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