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Literature DB >> 34856230

Ionic channels in nerve membranes, 50 years on.

Abstract

This retrospective traces the hypothesis of ion channels from an early statement in a 1970 essay in this journal (Hille, B., 1970, Prog. Biophys. Mol. Biol. 21, 1-32) to its realization today in biophysical, molecular, biochemical, and structural terms. The Na+ and K+ channels of the action potential have been isolated, reconstituted, cloned, mutated, and expressed. They are conformationally flexible, multi-pass glycosylated membrane proteins. Refined atomic structures of several conformational states are known. The discoveries over this half century history illustrate the growth of a field from initial ideas to a mature discipline of biology, physiology, and biomedical science.

Entities: Chemical

Keywords: Ca (2+) channel; K(+) channel; Na(+) channel

Mesh：

Substances：

Year: 2021 PMID： 34856230 PMCID： PMC8977236 DOI： 10.1016/j.pbiomolbio.2021.11.003

Source DB: PubMed Journal: Prog Biophys Mol Biol ISSN： 0079-6107 Impact factor: 3.667

76 in total

1. The architecture of active zone material at the frog's neuromuscular junction.

Authors: M L Harlow; D Ress; A Stoschek; R M Marshall; U J McMahan
Journal: Nature Date: 2001-01-25 Impact factor: 49.962

Review 2. Structural determinants and biophysical properties of HERG and KCNQ1 channel gating.

Authors: Martin Tristani-Firouzi; Michael C Sanguinetti
Journal: J Mol Cell Cardiol Date: 2003-01 Impact factor: 5.000

3. A quantitative description of membrane current and its application to conduction and excitation in nerve.

Authors: A L HODGKIN; A F HUXLEY
Journal: J Physiol Date: 1952-08 Impact factor: 5.182

4. Colocalization of ion channels involved in frequency selectivity and synaptic transmission at presynaptic active zones of hair cells.

Authors: W M Roberts; R A Jacobs; A J Hudspeth
Journal: J Neurosci Date: 1990-11 Impact factor: 6.167

5. The components of membrane conductance in the giant axon of Loligo.

Authors: A L HODGKIN; A F HUXLEY
Journal: J Physiol Date: 1952-04 Impact factor: 5.182

6. Primary structure of Electrophorus electricus sodium channel deduced from cDNA sequence.

Authors: M Noda; S Shimizu; T Tanabe; T Takai; T Kayano; T Ikeda; H Takahashi; H Nakayama; Y Kanaoka; N Minamino
Journal: Nature Date: 1984 Nov 8-14 Impact factor: 49.962

7. Structural basis for the modulation of voltage-gated sodium channels by animal toxins.

Authors: Huaizong Shen; Zhangqiang Li; Yan Jiang; Xiaojing Pan; Jianping Wu; Ben Cristofori-Armstrong; Jennifer J Smith; Yanni K Y Chin; Jianlin Lei; Qiang Zhou; Glenn F King; Nieng Yan
Journal: Science Date: 2018-07-26 Impact factor: 47.728

8. Proximal clustering between BK and Ca_V1.3 channels promotes functional coupling and BK channel activation at low voltage.

Authors: Oscar Vivas; Claudia M Moreno; Luis F Santana; Bertil Hille
Journal: Elife Date: 2017-06-30 Impact factor: 8.140

Ionic channels in nerve membranes, 50 years on.

1. The architecture of active zone material at the frog's neuromuscular junction.

Review 2. Structural determinants and biophysical properties of HERG and KCNQ1 channel gating.

3. A quantitative description of membrane current and its application to conduction and excitation in nerve.

4. Colocalization of ion channels involved in frequency selectivity and synaptic transmission at presynaptic active zones of hair cells.

5. The components of membrane conductance in the giant axon of Loligo.

6. Primary structure of Electrophorus electricus sodium channel deduced from cDNA sequence.

7. Structural basis for the modulation of voltage-gated sodium channels by animal toxins.

8. Proximal clustering between BK and Ca_V1.3 channels promotes functional coupling and BK channel activation at low voltage.

Review 9. New insights into K_ATP channel gene mutations and neonatal diabetes mellitus.

10. Destruction of sodium conductance inactivation in squid axons perfused with pronase.

Review 1. Druggability of Voltage-Gated Sodium Channels-Exploring Old and New Drug Receptor Sites.

Review 2. Structural determinants and biophysical properties of HERG and KCNQ1 channel gating.

Review 9. New insights into KATP channel gene mutations and neonatal diabetes mellitus.

Review 1. Druggability of Voltage-Gated Sodium Channels-Exploring Old and New Drug Receptor Sites.

Review 9. New insights into K_ATP channel gene mutations and neonatal diabetes mellitus.