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Literature DB >> 3485605

A derivative of an ataxia-telangiectasia (A-T) cell line with normal radiosensitivity but A-T-like inhibition of DNA synthesis.

A R Lehmann, C F Arlett, J F Burke, M H Green, M R James, J E Lowe.

Abstract

Ataxia-telangiectasia (A-T) cells are hypersensitive to the lethal effects of ionizing radiation and fail to inhibit DNA synthesis following radiation exposure. A cell line derived from an A-T line following DNA-mediated gene transfer has normal radiation sensitivity, but the kinetics of DNA synthesis after gamma-irradiation are similar to those of A-T cells.

Entities: Disease

Mesh：

Substances：
Cobalt Radioisotopes
DNA

Year: 1986 PMID： 3485605 DOI： 10.1080/09553008514552881

Source DB: PubMed Journal: Int J Radiat Biol Relat Stud Phys Chem Med ISSN： 0020-7616

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Cited

11 in total

1. Noncomplementation of radiation-induced chromosome aberrations in ataxia-telangiectasia/ataxia-telangiectasia-variant heterodikaryons.

Authors: M Stumm; K Sperling; R D Wegner
Journal: Am J Hum Genet Date: 1997-05 Impact factor: 11.025

2. The effect of hypothermic treatment on the repair or expression of X-ray damage measured in split dose experiments on L5178Y-S cells.

Authors: M Kapiszewska; C S Lange
Journal: Radiat Environ Biophys Date: 1989 Impact factor: 1.925

Review 3. Regulation of the cell cycle following DNA damage in normal and Ataxia telangiectasia cells.

Authors: H D Lohrer
Journal: Experientia Date: 1996-04-15

4. A high frequency of distinct ATM gene mutations in ataxia-telangiectasia.

Authors: J Wright; S Teraoka; S Onengut; A Tolun; R A Gatti; H D Ochs; P Concannon
Journal: Am J Hum Genet Date: 1996-10 Impact factor: 11.025

Review 5. Cellular and molecular consequences of defective Fanconi anemia proteins in replication-coupled DNA repair: mechanistic insights.

Authors: Larry H Thompson; John M Hinz
Journal: Mutat Res Date: 2009-02-21 Impact factor: 2.433

Review 6. Ataxia-telangiectasia: an inherited disorder of ionizing-radiation sensitivity in man. Progress in the elucidation of the underlying biochemical defect.

Authors: P J McKinnon
Journal: Hum Genet Date: 1987-03 Impact factor: 4.132

A derivative of an ataxia-telangiectasia (A-T) cell line with normal radiosensitivity but A-T-like inhibition of DNA synthesis.

1. Noncomplementation of radiation-induced chromosome aberrations in ataxia-telangiectasia/ataxia-telangiectasia-variant heterodikaryons.

2. The effect of hypothermic treatment on the repair or expression of X-ray damage measured in split dose experiments on L5178Y-S cells.

Review 3. Regulation of the cell cycle following DNA damage in normal and Ataxia telangiectasia cells.

4. A high frequency of distinct ATM gene mutations in ataxia-telangiectasia.

Review 5. Cellular and molecular consequences of defective Fanconi anemia proteins in replication-coupled DNA repair: mechanistic insights.

Review 6. Ataxia-telangiectasia: an inherited disorder of ionizing-radiation sensitivity in man. Progress in the elucidation of the underlying biochemical defect.

7. Radioresistant DNA synthesis and human genetic diseases.

8. Studies on phenotypic complementation of ataxia-telangiectasia cells by chromosome transfer.

9. Variant forms of ataxia telangiectasia.

Review 10. Cell cycle regulation in response to DNA damage in mammalian cells: a historical perspective.