Literature DB >> 3485563

Influence of tumour carriage on the production of lymphokines affecting macrophage behaviour.

L C McIntosh, L M Morrice, Y Udagawa, A W Thomson.   

Abstract

Normal and cyclophosphamide (Cy)-enhanced delayed-type hypersensitivity (DTH) reactions to sheep red blood cells (SRBC) were severely impaired in CD1 mice injected with 10(6) viable Landschütz ascites carcinoma (LAC) cells at the time of immunization. The tumour-induced suppression of DTH was accompanied by inhibition of splenic T-lymphocyte responses to antigen and mitogen. This was assessed by measuring lymphocyte transformation and the production of two lymphokines affecting macrophage behavior, i.e. lymphocyte-derived chemotactic factor (LDCF) and macrophage procoagulant-inducing factor (MPIF). Our results imply that impaired production/function of lymphokines affecting macrophage behaviour may play a key role in tumour-induced suppression of cell-mediated immunity and that this inhibition is independent of Cy-sensitive suppressor cells.

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Year:  1986        PMID： 3485563      PMCID： PMC1453823     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  28 in total

Review 1.  Suppressor cells: permitters and promoters of malignancy?

Authors:  D Naor
Journal:  Adv Cancer Res       Date:  1979       Impact factor: 6.242

Review 2.  Purification and characterization of lymphokines: an approach to the study of molecular mechanisms of cell-mediated immunity.

Authors:  M K Gately; M M Mayer
Journal:  Prog Allergy       Date:  1978

3.  Two distinct populations of suppressor cells in the spleens of mice bearing methylcholanthrene-induced tumors.

Authors:  B L Pope; R B Whitney; J G Levy
Journal:  J Immunol       Date:  1978-06       Impact factor: 5.422

4.  Difference in thymus dependency between effector and suppressor T cells for delayed footpad reaction to sheep erythrocytes in mice.

Authors:  Y Shimamoto; C Kubo; K Taniguchi; K Nomoto
Journal:  Cell Immunol       Date:  1981-06       Impact factor: 4.868

5.  Isolation of an inhibitor of type II interferon induction from tumor ascitic fluids.

Authors:  S Matsubara; M Suzuki; M Nakamura; K Edo; N Ishida
Journal:  Cancer Res       Date:  1980-07       Impact factor: 12.701

6.  Effects of murine tumors on delayed hypersensitivity to dinitrochlorobenzene. I. Description of anergy caused by transplanted tumors.

Authors:  J M Jessup; M H Cohen; M M Tomaszewski; E L Felix
Journal:  J Natl Cancer Inst       Date:  1976-11       Impact factor: 13.506

7.  Macrophages and resistance to tumours. I. Inhibition of delayed-type hypersensitivity reactions by tumour cells and by soluble prducts affecting macrophages.

Authors:  M Nelson; D S Nelson
Journal:  Immunology       Date:  1978-02       Impact factor: 7.397

8.  Tumour-induced suppression of delayed-type hypersensitivity in the mouse: independence of cyclophosphamide-sensitive suppressor cells.

Authors:  L C McIntosh; R G Pugh-Humphreys; A W Thomson
Journal:  Int Arch Allergy Appl Immunol       Date:  1985

9.  Active suppression of 1-fluoro-2,4-dinitrobenzene-immune T cells. Requirement of an auxiliary T cell induced by antigen.

Authors:  M S Sy; S D Miller; J W Moorhead; H N Claman
Journal:  J Exp Med       Date:  1979-05-01       Impact factor: 14.307

10.  Effects of the Landschütz ascites carcinoma and ascitic fluid on macrophage activity in C. parvum-injected mice.

Authors:  L C McIntosh; R G Pugh-Humphreys; A W Thomson
Journal:  Br J Cancer       Date:  1981-04       Impact factor: 7.640
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  7 in total

1.  Effects of L2C leukemia on macrophage-mediated responses.

Authors:  D P Collins
Journal:  Cancer Immunol Immunother       Date:  1987       Impact factor: 6.968

2.  Immunosuppressive activity of FK-506 in rats: flow cytometric analysis of lymphocyte populations in blood, spleen and thymus during treatment and following drug withdrawal.

Authors:  J Woo; C S Ross; J I Milton; A W Thomson
Journal:  Clin Exp Immunol       Date:  1990-01       Impact factor: 4.330

3.  Augmentation of delayed-type hypersensitivity to high dose sheep erythrocytes by cyclosporin A in the mouse: influence of drug dosage and route of administration and analysis of spleen cell populations.

Authors:  L M Webster; A W Thomson
Journal:  Clin Exp Immunol       Date:  1988-01       Impact factor: 4.330

4.  Anti-schistosomal activity of cyclosporin A: studies on murine spleen cells and the influence of a cyclosporin antagonist on resistance to infection.

Authors:  L R Brannan; L H Chappell; J Woo; A W Thomson
Journal:  Immunology       Date:  1989-07       Impact factor: 7.397

5.  The influence of FK-506 on the thymus: an immunophenotypic and structural analysis.

Authors:  R G Pugh-Humphreys; C S Ross; A W Thomson
Journal:  Immunology       Date:  1990-07       Impact factor: 7.397

6.  Influence of FK506 and cyclosporin A on alloantibody production and lymphocyte activation following blood transfusion.

Authors:  J Woo; D J Propper; A M Macleod; A W Thomson
Journal:  Clin Exp Immunol       Date:  1990-12       Impact factor: 4.330

7.  Cyclosporin A prevents suppression of delayed-type hypersensitivity in mice immunized with high-dose sheep erythrocytes.

Authors:  L M Webster; A W Thomson
Journal:  Immunology       Date:  1987-03       Impact factor: 7.397
  7 in total

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