Literature DB >> 3485538

Morphogenesis of human colon cancer cells with fetal rat mesenchymes in organ culture.

H Fukamachi, T Mizuno, Y S Kim.   

Abstract

The morphogenesis and cytodifferentiation of human colon cancer cells (LS174T and HT29) were examined by combining cancer cells with fetal rat digestive-tract mesenchyme in organ culture. LS174T cells migrated into the mesenchyme to form glandular structures composed of single columnar cells with their nuclei oriented basally, while HT29 cells formed cell masses with little lumen formation. Immunohistochemical studies with antibodies against carcinoembryonic antigen and secretory components showed that the composition of cell surface glycoproteins was not necessarily reversed to the normal type, even when neoplastic cells exhibited normal glandular structures.

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Year:  1986        PMID： 3485538     DOI： 10.1007/BF01942518

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  14 in total

1.  Studies on translocation of immunoglobulins across intestinal epithelium. II. Immunoelectron-microscopic localization of immunoglobulins and secretory component in human intestinal mucosa.

Authors:  W R Brown; Y Isobe; P K Nakane
Journal:  Gastroenterology       Date:  1976-12       Impact factor: 22.682

2.  The role of intracellular lumina in the repolarization process of a colonic adenocarcinoma cell line.

Authors:  L Remy; J Marvaldi; S Rua; J Secchi; P Lechene de la Porte
Journal:  Virchows Arch B Cell Pathol Incl Mol Pathol       Date:  1984

3.  Epithelial-mesenchymal interactions in differentiation of stomach epithelium in fetal mice.

Authors:  H Fukamachi; T Mizuno; S Takayama
Journal:  Anat Embryol (Berl)       Date:  1979-10

4.  Formation of tight junctions in epithelial cells. I. Induction by proteases in a human colon carcinoma cell line.

Authors:  E Cohen; A Talmon; O Faff; A Bacher; Y Ben-Shaul
Journal:  Exp Cell Res       Date:  1985-01       Impact factor: 3.905

Review 5.  Recent aspects of tumor invasiveness.

Authors:  M M Mareel
Journal:  Int Rev Exp Pathol       Date:  1980

6.  Epithelial-mesenchymal interaction in differentiation of duodenal epithelium of fetal rats in organ culture.

Authors:  H Fukamachi; S Takayama
Journal:  Experientia       Date:  1980-03-15

7.  The induction of adenocarcinomatous differentiation in neoplastic bladder epithelium by an embryonic prostatic inductor.

Authors:  H Fujii; G R Cunha; J T Norman
Journal:  J Urol       Date:  1982-10       Impact factor: 7.450

8.  Distribution of oncodevelopmental markers in neoplastic cells: therapeutic implications.

Authors:  P K Nakane; T Watanabe
Journal:  J Histochem Cytochem       Date:  1984-08       Impact factor: 2.479

9.  Normal genetically mosaic mice produced from malignant teratocarcinoma cells.

Authors:  B Mintz; K Illmensee
Journal:  Proc Natl Acad Sci U S A       Date:  1975-09       Impact factor: 11.205

10.  Mechanisms of invasiveness of epithelial tumours: ultrastructure of the interactions of carcinoma cells with embryonic mesenchyme and epithelium.

Authors:  C Tickle; A Crawley; M Goodman
Journal:  J Cell Sci       Date:  1978-10       Impact factor: 5.285
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  1 in total

1.  Morphologic differentiation of colon carcinoma cell lines HT-29 and HT-29KM in rotating-wall vessels.

Authors:  T J Goodwin; J M Jessup; D A Wolf
Journal:  In Vitro Cell Dev Biol       Date:  1992-01
  1 in total

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