Jack C Lennon1, Stephen L Aita2, Victor A Del Bene3, Tasha Rhoads4, Zachary J Resch4, Janelle M Eloi2, Keenan A Walker5. 1. Department of Psychology, Adler University, Chicago, Illinois, USA. 2. Department of Psychiatry, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA. 3. Department of Neurology, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, USA. 4. Department of Psychology, Rosalind Franklin University of Medicine & Science, North Chicago, Illinois, USA. 5. Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute on Aging, Baltimore, Maryland, USA.
Abstract
INTRODUCTION: Although dementia prevalence differs by race, it remains unclear whether cognition and neuropsychiatric symptom severity differ between Black and White individuals with dementia. METHODS: Using National Alzheimer's Coordinating Center (NACC) data, we evaluated dementia prevalence in non-Hispanic Black and White participants and compared their clinicodemographic characteristics. We examined race differences in cognition, neuropsychiatric symptoms, and functional abilities in participants with dementia using multivariable linear and logistic regression models. RESULTS: We included 5,700 Black and 31,225 White participants across 39 Alzheimer's Disease Research Centers. Of these, 1,528 (27%) Black and 11,267 (36%) White participants had dementia diagnoses. Despite having lower dementia prevalence, risk factors were more prevalent among Black participants. Black participants with dementia showed greater cognitive deficits, neuropsychiatric symptoms/severity, and functional dependence. DISCUSSION: Despite lower dementia prevalence, Black participants with dementia had more dementia risk factors, as well as greater cognitive impairment and neuropsychiatric symptom severity than White participants.
INTRODUCTION: Although dementia prevalence differs by race, it remains unclear whether cognition and neuropsychiatric symptom severity differ between Black and White individuals with dementia. METHODS: Using National Alzheimer's Coordinating Center (NACC) data, we evaluated dementia prevalence in non-Hispanic Black and White participants and compared their clinicodemographic characteristics. We examined race differences in cognition, neuropsychiatric symptoms, and functional abilities in participants with dementia using multivariable linear and logistic regression models. RESULTS: We included 5,700 Black and 31,225 White participants across 39 Alzheimer's Disease Research Centers. Of these, 1,528 (27%) Black and 11,267 (36%) White participants had dementia diagnoses. Despite having lower dementia prevalence, risk factors were more prevalent among Black participants. Black participants with dementia showed greater cognitive deficits, neuropsychiatric symptoms/severity, and functional dependence. DISCUSSION: Despite lower dementia prevalence, Black participants with dementia had more dementia risk factors, as well as greater cognitive impairment and neuropsychiatric symptom severity than White participants.
Authors: Saikat Chakraborty; Jack C Lennon; Sridhar A Malkaram; Yan Zeng; Daniel W Fisher; Hongxin Dong Journal: Neurosci Lett Date: 2019-04-01 Impact factor: 3.046
Authors: Ilene H Zuckerman; Priscilla T Ryder; Linda Simoni-Wastila; Thomas Shaffer; Masayo Sato; Lirong Zhao; Bruce Stuart Journal: J Gerontol B Psychol Sci Soc Sci Date: 2008-09 Impact factor: 4.077
Authors: Lei Yu; Michael W Lutz; Robert S Wilson; Daniel K Burns; Allen D Roses; Ann M Saunders; Jingyun Yang; Chris Gaiteri; Philip L De Jager; Lisa L Barnes; David A Bennett Journal: PLoS One Date: 2017-07-03 Impact factor: 3.240
Authors: Sandra Weintraub; Lilah Besser; Hiroko H Dodge; Merilee Teylan; Steven Ferris; Felicia C Goldstein; Bruno Giordani; Joel Kramer; David Loewenstein; Dan Marson; Dan Mungas; David Salmon; Kathleen Welsh-Bohmer; Xiao-Hua Zhou; Steven D Shirk; Alireza Atri; Walter A Kukull; Creighton Phelps; John C Morris Journal: Alzheimer Dis Assoc Disord Date: 2018 Jan-Mar Impact factor: 2.703
Authors: Anna Dittrich; Nicholas J Ashton; Henrik Zetterberg; Kaj Blennow; Joel Simrén; Fiona Geiger; Anna Zettergren; Sara Shams; Alejandra Machado; Eric Westman; Michael Schöll; Ingmar Skoog; Silke Kern Journal: Alzheimers Dement (Amst) Date: 2022-03-05