Literature DB >> 34853968

Metabolism of Subchondral Bone Tissue in Posttraumatic Osteoarthrosis in Rats.

R А Zubavlenko1, S V Belova2, V Yu Ulyanov2.   

Abstract

In rats with modeled posttraumatic knee osteoarthrosis, negative changes in subchondral bone metabolism were revealed: a tendency to an increase in osteocalcin concentration, a decrease in sclerostin and osteoprotegerin levels, and a significant increase in FGF-23 concentration accompanied by a slight elevation of inorganic phosphorous and significant increase in total calcium levels in comparison with the corresponding parameters in intact controls. These findings demonstrate crucial importance of structural integrity of the subchondral bone, because its protection improves the results of reconstructive therapy for local cartilage defects.
© 2021. Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  fibroblast growth factor-23; osteocalcin; osteoprotegerin; posttraumatic osteoarthrosis; sclerostin

Mesh：

Substances：

Year:  2021        PMID： 34853968     DOI： 10.1007/s10517-021-05363-5

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  6 in total

1.  Soluble receptor activator of nuclear factor kappaB ligand-osteoprotegerin ratio predicts survival in multiple myeloma: proposal for a novel prognostic index.

Authors:  Evangelos Terpos; Richard Szydlo; Jane F Apperley; Evdoxia Hatjiharissi; Marianna Politou; John Meletis; Nora Viniou; Xenophon Yataganas; John M Goldman; Amin Rahemtulla
Journal:  Blood       Date:  2003-04-10       Impact factor: 22.113

2.  Increased chondrocyte sclerostin may protect against cartilage degradation in osteoarthritis.

Authors:  B Y Chan; E S Fuller; A K Russell; S M Smith; M M Smith; M T Jackson; M A Cake; R A Read; J F Bateman; P N Sambrook; C B Little
Journal:  Osteoarthritis Cartilage       Date:  2011-05-12       Impact factor: 6.576

3.  Bone Tissue Metabolism in Dynamics of Experimental Knee Osteoarthrosis Induced by Dexamethasone and Talcum.

Authors:  E V Gladkova; Yu K Gladkova; V Yu Ulyanov
Journal:  Bull Exp Biol Med       Date:  2021-04-24       Impact factor: 0.804

Review 4.  Alterations of the subchondral bone in osteochondral repair--translational data and clinical evidence.

Authors:  P Orth; M Cucchiarini; D Kohn; H Madry
Journal:  Eur Cell Mater       Date:  2013-06-28       Impact factor: 3.942

5.  Sclerostin and the regulation of bone formation: Effects in hip osteoarthritis and femoral neck fracture.

Authors:  Jon Power; Kenneth E S Poole; Rutger van Bezooijen; Michael Doube; Ana M Caballero-Alías; Clemens Lowik; Socrates Papapoulos; Jonathan Reeve; Nigel Loveridge
Journal:  J Bone Miner Res       Date:  2010-08       Impact factor: 6.741

Review 6.  The role of TNF-receptor family members and other TRAF-dependent receptors in bone resorption.

Authors:  E M Gravallese; D L Galson; S R Goldring; P E Auron
Journal:  Arthritis Res       Date:  2000-11-02
  6 in total

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