Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Cloned cytotoxic T lymphocytes that recognize an I-A region product in the context of a class I antigen.

Literature DB >> 3485175

Cloned cytotoxic T lymphocytes that recognize an I-A region product in the context of a class I antigen.

Abstract

Cloned CTLs QM3 and QM7 isolated from a bulk CTL line B10.QBR anti-B10.MBR recognized a combination of the H-2Kb molecule and an I-Ak subregion gene product. Such a combinatorial specificity was revealed by complementation of the target antigen in F1 animals between two negative parental strains carrying H-2Kb and I-Ak, respectively. We confirmed the involvement of the H-2Kb molecule by blocking killing with anti-Kb mAb and failure of certain mutant H-2Kb genes to complement with I-Ak to generate the determinant in F1 animals. Although the nature of the I-Ak subregion gene product is not definitive, there was a correlation between the expression of Ia antigens on the cell surface and susceptibility of the cells to lysis by these CTLs, suggesting that it is the classical I-Ak class II antigen.

Mesh：

Substances：

Year: 1986 PMID： 3485175 PMCID： PMC2188072 DOI： 10.1084/jem.163.4.972

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

15 in total

1. Two new recombinant H-2 haplotypes, one of which juxtaposes Kb and Ik alleles.

Authors: D H Sachs; J S Arn; T H Hansen
Journal: J Immunol Date: 1979-11 Impact factor: 5.422

2. Specificity, phenotype, and precursor frequency of primary cytolytic T lymphocytes specific for class II major histocompatibility antigens.

Authors: H Golding; A Singer
Journal: J Immunol Date: 1985-09 Impact factor: 5.422

3. Properties of monoclonal antibodies to mouse Ig allotypes, H-2, and Ia antigens.

Authors: V T Oi; P P Jones; J W Goding; L A Herzenberg; L A Herzenberg
Journal: Curr Top Microbiol Immunol Date: 1978 Impact factor: 4.291

4. Significance of Lyt phenotypes: Lyt2 antibodies block activities of T cells that recognize class 1 major histocompatibility complex antigens regardless of their function.

Authors: S L Swain
Journal: Proc Natl Acad Sci U S A Date: 1981-11 Impact factor: 11.205

5. Lyt phenotypes of primary cytotoxic T cells generated across the A and E region of the H-2 complex.

Authors: D Vidovic; A Juretic; Z A Nagy; J Klein
Journal: Eur J Immunol Date: 1981-06 Impact factor: 5.532

6. History and genealogy of the H-2Kb mutants from the C57BL/6Kh colony.

Authors: R W Melvold; H I Kohn; G R Dunn
Journal: Immunogenetics Date: 1982 Impact factor: 2.846

7. Monoclonal antibodies to mouse MHC antigens. III. Hybridoma antibodies reacting to antigens of the H-2b haplotype reveal genetic control of isotype expression.

Authors: K Ozato; D H Sachs
Journal: J Immunol Date: 1981-01 Impact factor: 5.422

8. Hybridoma cell lines secreting monoclonal antibodies to mouse H-2 and Ia antigens.

Authors: K Ozato; N Mayer; D H Sachs
Journal: J Immunol Date: 1980-02 Impact factor: 5.422

9. Histocompatibility antigens controlled by the I region of the murine H-2 complex. II. K/D region compatibility is not required for I-region cell-mediated lymphocytotoxicity.

Authors: J Klein; C L Chiang; V Hauptfeld
Journal: J Exp Med Date: 1977-02-01 Impact factor: 14.307

5. Cell-cell interaction in graft rejection responses: induction of anti-allo-class I H-2 tolerance is prevented by immune responses against allo-class II H-2 antigens coexpressed on tolerogen.

Authors: S Hori; S Kitagawa; H Iwata; T Ochiai; K Isono; T Hamaoka; H Fujiwara
Journal: J Exp Med Date: 1992-01-01 Impact factor: 14.307

5 in total

Cloned cytotoxic T lymphocytes that recognize an I-A region product in the context of a class I antigen.

1. Two new recombinant H-2 haplotypes, one of which juxtaposes Kb and Ik alleles.

2. Specificity, phenotype, and precursor frequency of primary cytolytic T lymphocytes specific for class II major histocompatibility antigens.

3. Properties of monoclonal antibodies to mouse Ig allotypes, H-2, and Ia antigens.

4. Significance of Lyt phenotypes: Lyt2 antibodies block activities of T cells that recognize class 1 major histocompatibility complex antigens regardless of their function.

5. Lyt phenotypes of primary cytotoxic T cells generated across the A and E region of the H-2 complex.

6. History and genealogy of the H-2Kb mutants from the C57BL/6Kh colony.

7. Monoclonal antibodies to mouse MHC antigens. III. Hybridoma antibodies reacting to antigens of the H-2b haplotype reveal genetic control of isotype expression.

8. Hybridoma cell lines secreting monoclonal antibodies to mouse H-2 and Ia antigens.

9. Histocompatibility antigens controlled by the I region of the murine H-2 complex. II. K/D region compatibility is not required for I-region cell-mediated lymphocytotoxicity.

10. Two-gene control of the expression of a murine Ia antigen.

1. Different recognition of transgenic HLA-DQw6 molecules by mouse CD4+ and CD8+ T cells.

2. Growth stimulation of tumor-specific cytotoxic T lymphocytes on concanavalin a-immobilized carrier beads.

3. Recognition of HLA-B27 by mouse cytotoxic T-cell clones: a transgenic mouse model.

4. Qa-1/Tla region alloantigen-specific CTL with alpha beta receptor.

5. Cell-cell interaction in graft rejection responses: induction of anti-allo-class I H-2 tolerance is prevented by immune responses against allo-class II H-2 antigens coexpressed on tolerogen.