Gilbert T Chua1,2, Mike Yat Wah Kwan3, Celine S L Chui4,5,6, Robert David Smith4, Edmund Chi Lok Cheung7, Tian Ma6, Miriam T Y Leung6,7, Sabrina Siu Ling Tsao1,2, Elaine Kan8, Wing Kei Carol Ng8, Victor Chi Man Chan9, Shuk Mui Tai9, Tak Ching Yu9, Kwok Piu Lee9, Joshua Sung Chih Wong3, Ying Kit Lin3, Chi Chiu Shek3, Agnes Sze Yin Leung10, Chit Kwong Chow11, Ka Wah Li12, Johnny Ma13,14,15,16, Wai Yuk Fung13,14,15,16, Daniel Lee17, Ming Yen Ng18,19, Wilfred Hing Sang Wong1, Hing Wai Tsang1, Janette Kwok20, Daniel Leung1, Kin Lai Chung21, Chun Bong Chow1, Godfrey Chi Fung Chan1,2, Wing Hang Leung1,2, Kelvin Kai Wang To22, Kwok Yung Yuen22, Yu Lung Lau1,2, Ian Chi Kei Wong6,7,23, Patrick Ip1. 1. Department of Pediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. 2. Department of Paediatrics, Hong Kong Children's Hospital, Hong Kong SAR, China. 3. Department of Pediatrics and Adolescent Medicine, Princess Margaret Hospital, Hong Kong SAR, China. 4. School of Nursing, The University of Hong Kong, Hong Kong SAR, China. 5. School of Public Health, The University of Hong Kong, Hong Kong SAR, China. 6. Laboratory of Data Discovery for Health (D24H), Hong Kong Science and Technology Park, Hong Kong SAR, China. 7. Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong SAR, China. 8. Department of Radiology, Hong Kong Children's Hospital, Hong Kong SAR, China. 9. Department of Paediatrics and Adolescent Medicine, Pamela Youde Nethersole Eastern Hospital, Hong Kong SAR, China. 10. Department of Pediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China. 11. Department of Pediatrics and Adolescent Medicine, United Christian Hospital, Hong Kong SAR, China. 12. Department of Pediatrics and Adolescent Medicine, Tuen Mun Hospital, Hong Kong SAR, China. 13. Department of Radiology, Caritas Medical Centre, Hong Kong SAR, China. 14. Department of Radiology, North Landau Hospital, Hong Kong SAR, China. 15. Department of Radiology, Princess Margaret Hospital, Hong Kong SAR, China. 16. Department of Radiology, Yan Chai Hospital, Hong Kong SAR, China. 17. Department of Radiology, Pamela Youde Nethersole Eastern Hospital, Hong Kong SAR, China. 18. Department of Diagnostic Radiology, The University of Hong Kong, China. 19. Department of Medical Imaging, The University of Hong Kong-Shenzhen Hospital, China. 20. Division of Transplantation and Immunogenetics, Department of Pathology, Queen Mary Hospital, Hong Kong SAR, China. 21. Quality and Safety Division, Hospital Authority Head office, Hong Kong SAR, China. 22. Department of Microbiology, Carol Yu Centre for Infection, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. 23. Research Department of Practice and Policy, UCL School of Pharmacy, University College, London, United Kingdom.
Abstract
BACKGROUND: Age-specific incidence of acute myocarditis/pericarditis in adolescents following Comirnaty vaccination in Asia is lacking. This study aimed to study the clinical characteristics and incidence of acute myocarditis/pericarditis among Hong Kong adolescents following Comirnaty vaccination. METHODS: This is a population cohort study in Hong Kong that monitored adverse events following immunization through a pharmacovigilance system for coronavirus disease 2019 (COVID-19) vaccines. All adolescents aged between 12 and 17 years following Comirnaty vaccination were monitored under the COVID-19 vaccine adverse event response and evaluation program. The clinical characteristics and overall incidence of acute myocarditis/pericarditis in adolescents following Comirnaty vaccination were analyzed. RESULTS: Between 14 June 2021 and 4 September 2021, 33 Chinese adolescents who developed acute myocarditis/pericarditis following Comirnaty vaccination were identified. In total, 29 (87.88%) were male and 4 (12.12%) were female, with a median age of 15.25 years. And 27 (81.82%) and 6 (18.18%) cases developed acute myocarditis/pericarditis after receiving the second and first dose, respectively. All cases are mild and required only conservative management. The overall incidence of acute myocarditis/pericarditis was 18.52 (95% confidence interval [CI], 11.67-29.01) per 100 000 persons vaccinated. The incidence after the first and second doses were 3.37 (95% CI, 1.12-9.51) and 21.22 (95% CI, 13.78-32.28 per 100 000 persons vaccinated, respectively. Among male adolescents, the incidence after the first and second doses were 5.57 (95% CI, 2.38-12.53) and 37.32 (95% CI, 26.98-51.25) per 100 000 persons vaccinated. CONCLUSIONS: There is a significant increase in the risk of acute myocarditis/pericarditis following Comirnaty vaccination among Chinese male adolescents, especially after the second dose.
BACKGROUND: Age-specific incidence of acute myocarditis/pericarditis in adolescents following Comirnaty vaccination in Asia is lacking. This study aimed to study the clinical characteristics and incidence of acute myocarditis/pericarditis among Hong Kong adolescents following Comirnaty vaccination. METHODS: This is a population cohort study in Hong Kong that monitored adverse events following immunization through a pharmacovigilance system for coronavirus disease 2019 (COVID-19) vaccines. All adolescents aged between 12 and 17 years following Comirnaty vaccination were monitored under the COVID-19 vaccine adverse event response and evaluation program. The clinical characteristics and overall incidence of acute myocarditis/pericarditis in adolescents following Comirnaty vaccination were analyzed. RESULTS: Between 14 June 2021 and 4 September 2021, 33 Chinese adolescents who developed acute myocarditis/pericarditis following Comirnaty vaccination were identified. In total, 29 (87.88%) were male and 4 (12.12%) were female, with a median age of 15.25 years. And 27 (81.82%) and 6 (18.18%) cases developed acute myocarditis/pericarditis after receiving the second and first dose, respectively. All cases are mild and required only conservative management. The overall incidence of acute myocarditis/pericarditis was 18.52 (95% confidence interval [CI], 11.67-29.01) per 100 000 persons vaccinated. The incidence after the first and second doses were 3.37 (95% CI, 1.12-9.51) and 21.22 (95% CI, 13.78-32.28 per 100 000 persons vaccinated, respectively. Among male adolescents, the incidence after the first and second doses were 5.57 (95% CI, 2.38-12.53) and 37.32 (95% CI, 26.98-51.25) per 100 000 persons vaccinated. CONCLUSIONS: There is a significant increase in the risk of acute myocarditis/pericarditis following Comirnaty vaccination among Chinese male adolescents, especially after the second dose.
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