Shao-Hua Hu1,2,3,4, Hai-Mei Li1,2, Hao Yu5, Yan Liu6, Chen-Xing Liu7, Xian-Bo Zuo8, Jing Lu1,2, Jia-Jun Jiang1,2, Cai-Xi Xi1,2, Bo-Chao Huang1,2, Hu-Ji Xu9, Jian-Bo Hu1,2, Jian-Bo Lai1,2, Man-Li Huang1,2, Jian-Ning Liu10, Dan-Ge Xu11, Xi-Chao Guo10, Wei Wu11, Xin Wu12, Lei Jiang12, Meng Li12, Guang-Ping Zhang10, Jin-Wen Huang1, Ning Wei1,2, Wen Lv13, Jin-Feng Duan1, Hong-Li Qi1, Chan-Chan Hu1, Jing-Kai Chen1, Wei-Hua Zhou1,2, Wei-Juan Xu1,2, Chen-Feng Liu14, Hai-Yong Liang15, Jing Du16, Shu-Fa Zheng10, Qiao-Ling Lu17, Lin Zheng18, Xiao-Wei Hu10, Feng-Xiang Chen10, Peng Chen19, Biao Zhu20, Li-Jun Xu20, Zhi-Min Ni21, Ye-Zhen Fang22, Zuo-Kai Yang17, Xin-Ren Shan17, En-de Zheng23, Fan Zhang24, Qing-Qing Zhou24, Yi Rao6,25, Dick Swaab26, Wei-Hua Yue27,28,29, Yi Xu30,31,32,33. 1. Department of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. 2. The Key Laboratory of Mental Disorder Management in Zhejiang Province, Hangzhou, Zhejiang, China. 3. National Human Brain Bank for Health and Disease, Hangzhou, Zhejiang, China. 4. Brain Research Institute, Zhejiang University, Hangzhou, Zhejiang, China. 5. Department of Psychiatry, Jining Medical University, 133 Hehua Rd, Jining, Shandong, China. 6. Department of Neurobiology, School of Basic Medical Sciences, Capital Medical University, Beijing, China. 7. Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA. 8. Institute of Dermatology and Department of Dermatology at First Hospital, Anhui Medical University, Hefei, Anhui, China. 9. Department of General Office, Center for Disease Control of Jianggan District, Hangzhou, Zhejiang, China. 10. Department of Clinical Laboratory, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. 11. State Key Laboratory for Diagnosis and Treatment of Infectious Disease, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. 12. Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, The Second Military Medial University, Shanghai, China. 13. Department of Psychiatry, Seventh Hangzhou Hospital, Hangzhou, Zhejiang, China. 14. Medicines & Biochemical Products Branch, Zhejiang Medicine & Health Products I/E CO., Ltd, Hangzhou, Zhejiang, China. 15. BioMiao Biological Technology (Beijing) Co., Ltd, Beijing, China. 16. Beijing Emei Tongde Technology Development Co., Ltd, Beijing, China. 17. Department of Aids Venereal Disease Control and Prevention, Shaoxing Center for Disease Control and Prevention, Shaoxing, Zhejiang, China. 18. Department of Prevention and Treatment of AIDS and Sexually Transmitted Diseases, Center for Disease Control and Prevention of Xihu District, Hangzhou, Zhejiang, China. 19. International Medical Center, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. 20. Department of Infectious Disease, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. 21. Department of Disease Control, Center for Disease Control of Jianggan District, Hangzhou, Zhejiang, China. 22. Department of Laboratory, Center for Disease Control of Jianggan District, Hangzhou, Zhejiang, China. 23. Beijing ViewSolid Biotechnology, Beijing, China. 24. Shanghai OE Biotech. Co., Ltd, Beijing, China. 25. Peking-Tsinghua Center for Life Sciences, PKU-IDG/McGovern Institute for Brain Research, Peking University School of Life Sciences, Beijing, China. 26. Netherlands Institute for Neuroscience, Amsterdam, 1105 BA, The Netherlands. 27. Institute of Mental Health, National Clinical Research Center for Mental Disorders, Peking University Sixth Hospital, Beijing, China. dryue@bjmu.edu.cn. 28. NHC Key Laboratory of Mental Health & Research Unit of Diagnosis and Treatment of Mood Cognitive Disorder (2018RU006), Chinese Academy of Medical Sciences, Beijing, China. dryue@bjmu.edu.cn. 29. PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China. dryue@bjmu.edu.cn. 30. Department of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. xuyizju@zju.edu.cn. 31. The Key Laboratory of Mental Disorder Management in Zhejiang Province, Hangzhou, Zhejiang, China. xuyizju@zju.edu.cn. 32. National Human Brain Bank for Health and Disease, Hangzhou, Zhejiang, China. xuyizju@zju.edu.cn. 33. Brain Research Institute, Zhejiang University, Hangzhou, Zhejiang, China. xuyizju@zju.edu.cn.
Correction to: Cell Discovery (2021) 7:10310.1038/s41421-021-00341-7, Published online 31 October 2021In the initial published version of this article[1], we missed some errors while proofreading the manuscript for the publication. The statistical values in Abstract and Results sections were inconsistent with those in Table 1. Upon careful examination of our original data, the second sentence in Abstract section should be “Here, we performed a two-stage genome-wide association study (GWAS) with a total sample of 1478 homosexual males and 3313 heterosexual males in Han Chinese populations and identified two genetic loci (rs17320865, Xq27.3, FMR1NB, P = 7.61 × 10−9, OR = 1.31; rs7259428, 19q12, ZNF536, P = 8.20 × 10−15, OR = 0.65) showing consistent association with male sexual orientation.” On page 2, the second column, the lines 28–35 should be “All four SNPs showed consistent association in the independent validation samples, and two SNPs reached a genome-wide significance level (P < 5 × 10−8) after meta-analysis, including SNP rs7259428 on chromosome 19q12 (located in ZNF536, P = 8.20 × 10−15, OR = 0.65; Fig. 1e and Table 1) and rs17320865 on chromosome Xq27.3 (located in FMR1NB, P = 7.61 × 10−9, OR = 1.31; Fig. 1d and Table 1).” In Table 1, the gene symbol ‘ZNF356’ should be ‘ZNF536’. The corrected version of the Table 1 is displayed below.
Table 1
Evidence of an association of the four SNPs in a two-stage GWAS in Han Chinese population.
Discovery stage (521 homosexual and 1270 heterosexual men)
Replication stage (957 homosexual and 2043 heterosexual men)
Meta-analysis (1478 homosexual and 3313 heterosexual men)
SNP
CHR
BP
A1/A2
Gene
OR
SE
P
OR
SE
P
OR
P
P_Het
rs17320865
X
147085464
A/T
FMR1NB
1.39
0.07
9.77 × 10−6
1.26
0.06
8.81 × 10−4
1.31
7.61 × 109
0.30
rs7259428
19
31104579
G/A
ZNF536
0.67
0.09
3.87 × 10−6
0.64
0.07
1.13 × 10−6
0.65
8.20 × 1015
0.69
rs12039940
1
181952711
C/T
ZNF648
1.57
0.10
9.22 × 10−6
1.01
0.04
8.72 × 10−1
1.07
6.28 × 102
1.0 × 10−4
rs7500300
16
5932886
C/T
RBFOX1
1.45
0.08
5.28 × 10−6
1.11
0.05
6.84 × 10−2
1.19
3.08 × 10−5
5.2 × 10−3
CHR chromosome, OR odds ratio, ORs were calculated according to the minor allele, A1/A2 minor/major allele, P_Het
p values of heterogeneity test.
Evidence of an association of the four SNPs in a two-stage GWAS in Han Chinese population.CHR chromosome, OR odds ratio, ORs were calculated according to the minor allele, A1/A2 minor/major allele, P_Het
p values of heterogeneity test.