Fiona Bragg1,2, Christiana Kartsonaki1,2, Yu Guo3, Michael Holmes1,2, Huaidong Du1,2, Canqing Yu4,5, Pei Pei6, Ling Yang1,2, Donghui Jin7, Yiping Chen1,2, Dan Schmidt1, Daniel Avery1, Jun Lv4,5, Junshi Chen8, Robert Clarke1,2, Michael Hill1, Liming Li4,5, Iona Millwood1,2, Zhengming Chen1,2. 1. Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, U.K. 2. Medical Research Council Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, U.K. 3. Fuwai Hospital Chinese Academy of Medical Sciences, National Center for Cardiovascular Diseases, Beijing, China. 4. Department of Epidemiology & Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China. 5. Peking University Center for Public Health and Epidemic Preparedness & Response, Beijing, China. 6. Chinese Academy of Medical Sciences, Beijing, China. 7. Hunan Centre for Disease Control and Prevention, Changsha, Hunan, China. 8. China National Center for Food Safety Risk Assessment, Beijing, China.
Abstract
OBJECTIVE: To assess prospective associations of circulating metabolites with the risk of type 2 diabetes (T2D) among Chinese adults. RESEARCH DESIGN AND METHODS: A case-cohort study within the 8-year prospective China Kadoorie Biobank comprised 882 participants with incident T2D and 789 subcohort participants. Nuclear magnetic resonance metabolomic profiling quantified 225 metabolites in stored baseline plasma samples. Cox regression related individual metabolites with T2D risk, adjusting for potential confounders and fasting time. RESULTS: After correction for multiple testing, 163 metabolites were significantly associated with the risk of T2D (P < 0.05). There were strong positive associations of VLDL particle size, the ratio of apolipoprotein B to apolipoprotein A-1, branched-chain amino acids, glucose, and triglycerides with T2D, and inverse associations of HDL-cholesterol, HDL particle size, and relative n-3 and saturated fatty acid concentrations. CONCLUSIONS: In Chinese adults, metabolites across diverse pathways were independently associated with T2D risk, providing valuable etiological insights and potential to improve T2D risk prediction.
OBJECTIVE: To assess prospective associations of circulating metabolites with the risk of type 2 diabetes (T2D) among Chinese adults. RESEARCH DESIGN AND METHODS: A case-cohort study within the 8-year prospective China Kadoorie Biobank comprised 882 participants with incident T2D and 789 subcohort participants. Nuclear magnetic resonance metabolomic profiling quantified 225 metabolites in stored baseline plasma samples. Cox regression related individual metabolites with T2D risk, adjusting for potential confounders and fasting time. RESULTS: After correction for multiple testing, 163 metabolites were significantly associated with the risk of T2D (P < 0.05). There were strong positive associations of VLDL particle size, the ratio of apolipoprotein B to apolipoprotein A-1, branched-chain amino acids, glucose, and triglycerides with T2D, and inverse associations of HDL-cholesterol, HDL particle size, and relative n-3 and saturated fatty acid concentrations. CONCLUSIONS: In Chinese adults, metabolites across diverse pathways were independently associated with T2D risk, providing valuable etiological insights and potential to improve T2D risk prediction.
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