| Literature DB >> 34847370 |
Daoming Wang1, Marwah Doestzada1, Lianmin Chen1, Sergio Andreu-Sánchez1, Inge C L van den Munckhof2, Hannah E Augustijn1, Martijn Koehorst3, Angel J Ruiz-Moreno1, Vincent W Bloks4, Niels P Riksen2, Joost H W Rutten2, Leo A B Joosten5, Mihai G Netea6, Cisca Wijmenga7, Alexandra Zhernakova7, Folkert Kuipers3, Jingyuan Fu8.
Abstract
Bile acids (BAs) facilitate intestinal fat absorption and act as important signaling molecules in host-gut microbiota crosstalk. BA-metabolizing pathways in the microbial community have been identified, but it remains largely unknown how the highly variable genomes of gut bacteria interact with host BA metabolism. We characterized 8,282 structural variants (SVs) of 55 bacterial species in the gut microbiomes of 1,437 individuals from two cohorts and performed a systematic association study with 39 plasma BA parameters. Both variations in SV-based continuous genetic makeup and discrete clusters showed correlations with BA metabolism. Metagenome-wide association analysis identified 809 replicable associations between bacterial SVs and BAs and SV regulators that mediate the effects of lifestyle factors on BA metabolism. This is the largest microbial genetic association analysis to demonstrate the impact of bacterial SVs on human BA composition, and it highlights the potential of targeting gut microbiota to regulate BA metabolism through lifestyle intervention.Entities:
Keywords: bacterial genetics; bile acid metabolism; human gut microbiome; metagenome; population-based cohort study; structural variation
Mesh：
Substances：
Year: 2021 PMID： 34847370 DOI： 10.1016/j.chom.2021.11.003
Source DB: PubMed Journal: Cell Host Microbe ISSN： 1931-3128 Impact factor: 21.023