Literature DB >> 3484717

Sister chromatid exchange in highly purified human B and T lymphocytes.

K Miller.   

Abstract

Sister chromatid exchange (SCE) rates were determined in human peripheral blood B and T lymphocyte populations highly purified by immunologic methods. The purified populations were supplemented with gamma-irradiated unseparated autologous mononuclear cells to restore helper-functions and stimulated with pokeweed mitogen (PWM) and phytohemagglutinin (PHA), respectively. Measured at the different peaks of proliferation after identical bromodeoxyuridine (BrdU) incubation times, T lymphocytes showed significantly higher SCE frequencies than B lymphocytes. In both populations, different proliferation kinetics and a different minimal BrdU concentration for sister chromatid differentiation (SCD) were observed.

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Year:  1986        PMID： 3484717     DOI： 10.1007/BF00283937

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  22 in total

1.  SIMPLIFIED MYELOPEROXIDASE STAIN USING BENZIDINE DIHYDROCHLORIDE.

Authors:  L S KAPLOW
Journal:  Blood       Date:  1965-08       Impact factor: 22.113

2.  Human B and T lymphocytes differ in UV-induced repair capacity.

Authors:  F H Yew; R T Johnson
Journal:  Exp Cell Res       Date:  1978-04       Impact factor: 3.905

3.  SCE in B and T lymphocytes. Possible implications for Bloom's syndrome.

Authors:  B Santesson; K Lindahl-Kiessling; A Mattsson
Journal:  Clin Genet       Date:  1979-08       Impact factor: 4.438

4.  Frequencies of sister-chromatid exchanges in relation to cell kinetics in lymphocyte cultures.

Authors:  E Giulotto; A Mottura; R Giorgi; L de Carli; F Nuzzo
Journal:  Mutat Res       Date:  1980-05       Impact factor: 2.433

5.  Cell-cycle duration and sister-chromatid exchange frequency in cultured human lymphocytes.

Authors:  A J Snope; J M Rary
Journal:  Mutat Res       Date:  1979-12       Impact factor: 2.433

6.  Separation of functional subsets of human T cells by a monoclonal antibody.

Authors:  E L Reinherz; P C Kung; G Goldstein; S F Schlossman
Journal:  Proc Natl Acad Sci U S A       Date:  1979-08       Impact factor: 11.205

7.  Cell cycle-dependent regulation of excision repair of UV damage.

Authors:  C S Downes; R T Johnson; A R Collins
Journal:  Exp Cell Res       Date:  1982-11       Impact factor: 3.905

8.  Activation of purified human thymus-derived (T) cells by mitogens. II. Monocyte- macrophage potentiation of mitogen-induced DNA synthesis.

Authors:  J R Schmidtke; S Hatfield
Journal:  J Immunol       Date:  1976-02       Impact factor: 5.422

9.  Dependency of sister chromatid exchange in T- and B-cells on the incorporation of deoxyribonucleosides into chromosomal DNA.

Authors:  Y Shiraishi; H Weinfeld; J Minowada; A A Sandberg
Journal:  J Natl Cancer Inst       Date:  1976-12       Impact factor: 13.506

10.  Hybridization with human cells corrects the elevated SCE frequency and BrdU hypersensitivity of hamster cell line EM9.

Authors:  J H Ray; E Louie; J German
Journal:  Cytogenet Cell Genet       Date:  1985
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  1 in total

1.  SCE variability in lymphocytes and fibroblasts. A controlled study.

Authors:  T Lukusa; P Vercauteren; H Van den Berghe; J J Cassiman
Journal:  Hum Genet       Date:  1988-10       Impact factor: 4.132
  1 in total

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