Literature DB >> 34846405

Glutathione peroxidase mimics based on conformationally-restricted, peri-like, 4,5-disubstituted fluorene dichalcogenides.

Kesar Jagdev1, Damiano Tanini2, Jack W Lownes1, Carlotta Figliola1, Louise Male1, Antonella Capperucci2, Richard S Grainger1.   

Abstract

Glutathione peroxidase (GPx) regulates cellular peroxide levels through glutathione oxidation. GPx-mimics based on 4,5-disubstituted fluorene diselenides, their oxides, and ditellurides show catalytic activities consistent with conformational restriction about the dichalcogen bond.

Entities:  

Year:  2021        PMID： 34846405     DOI： 10.1039/d1ob02153b

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  1 in total

1.  Synthesis, Catalytic GPx-like Activity, and SET Reactions of Conformationally Constrained 2,7-Dialkoxy-Substituted Naphthalene-1,8-peri-diselenides.

Authors:  Adrian I Doig; Tyler A Tuck; Brandon LeBlanc; Thomas G Back
Journal:  ACS Omega       Date:  2022-07-28
  1 in total

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