Literature DB >> 34845510

Acute kidney injury in pediatrics: an overview focusing on pathophysiology.

Ana Flávia Lima Ruas1, Gabriel Malheiros Lébeis1, Nicholas Bianco de Castro1, Vitória Andrade Palmeira1, Larissa Braga Costa1, Katharina Lanza1, Ana Cristina Simões E Silva2.   

Abstract

Acute kidney injury (AKI) is defined as an abrupt decline in glomerular filtration rate, with increased serum creatinine and nitrogenous waste products due to several possible etiologies. Incidence in the pediatric population is estimated to be 3.9 per 1,000 hospitalizations, and prevalence among children admitted to intensive care units is 26.9%. Despite being a condition with important incidence and morbimortality, further evidence on pathophysiology and management among the pediatric population is still lacking. This narrative review aimed to summarize and discuss current data on AKI pathophysiology in the pediatric population, considering all the physiological particularities of this age range and common etiologies. Additionally, we reported current diagnostic tools, novel biomarkers, and newly proposed medications that have been studied with the aim of early diagnosis and appropriate treatment of AKI in the future.
© 2021. The Author(s), under exclusive licence to International Pediatric Nephrology Association.

Entities:  

Keywords:  Acute kidney injury; Epidemiology; Pathophysiology; Pediatrics; Perspectives

Mesh：

Substances：

Year:  2021        PMID： 34845510     DOI： 10.1007/s00467-021-05346-8

Source DB:  PubMed          Journal:  Pediatr Nephrol        ISSN： 0931-041X            Impact factor:   3.651


  107 in total

1.  Creatinine as the gold standard for kidney injury biomarker studies?

Authors:  Sushrut S Waikar; Rebecca A Betensky; Joseph V Bonventre
Journal:  Nephrol Dial Transplant       Date:  2009-09-07       Impact factor: 5.992

Review 2.  Acute kidney injury.

Authors:  Claudio Ronco; Rinaldo Bellomo; John A Kellum
Journal:  Lancet       Date:  2019-11-23       Impact factor: 79.321

Review 3.  Global epidemiology and outcomes of acute kidney injury.

Authors:  Eric A J Hoste; John A Kellum; Nicholas M Selby; Alexander Zarbock; Paul M Palevsky; Sean M Bagshaw; Stuart L Goldstein; Jorge Cerdá; Lakhmir S Chawla
Journal:  Nat Rev Nephrol       Date:  2018-10       Impact factor: 28.314

Review 4.  Acute kidney injury.

Authors:  Rinaldo Bellomo; John A Kellum; Claudio Ronco
Journal:  Lancet       Date:  2012-05-21       Impact factor: 79.321

5.  AKI in hospitalized children: epidemiology and clinical associations in a national cohort.

Authors:  Scott M Sutherland; Jun Ji; Farnoosh H Sheikhi; Eric Widen; Lu Tian; Steven R Alexander; Xuefeng B Ling
Journal:  Clin J Am Soc Nephrol       Date:  2013-07-05       Impact factor: 8.237

Review 6.  Neonatal Acute Kidney Injury.

Authors:  David T Selewski; Jennifer R Charlton; Jennifer G Jetton; Ronnie Guillet; Maroun J Mhanna; David J Askenazi; Alison L Kent
Journal:  Pediatrics       Date:  2015-07-13       Impact factor: 7.124

Review 7.  A systematic review of RIFLE criteria in children, and its application and association with measures of mortality and morbidity.

Authors:  Morgan B Slater; Vijay Anand; Elizabeth M Uleryk; Christopher S Parshuram
Journal:  Kidney Int       Date:  2012-01-18       Impact factor: 10.612

8.  Epidemiology of Acute Kidney Injury in Critically Ill Children and Young Adults.

Authors:  Ahmad Kaddourah; Rajit K Basu; Sean M Bagshaw; Stuart L Goldstein
Journal:  N Engl J Med       Date:  2016-11-18       Impact factor: 91.245

9.  Electronic health record identification of nephrotoxin exposure and associated acute kidney injury.

Authors:  Stuart L Goldstein; Eric Kirkendall; Hovi Nguyen; Joshua K Schaffzin; John Bucuvalas; Tracey Bracke; Michael Seid; Marshall Ashby; Natalie Foertmeyer; Lori Brunner; Anne Lesko; Cynthia Barclay; Carole Lannon; Stephen Muething
Journal:  Pediatrics       Date:  2013-08-12       Impact factor: 7.124

Review 10.  Acute kidney injury in children.

Authors:  Sharon Phillips Andreoli
Journal:  Pediatr Nephrol       Date:  2008-12-13       Impact factor: 3.714
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  1 in total

1.  Evaluation of insertion/deletion (I/D) polymorphisms of ACE gene and circulating levels of angiotensin II in congenital anomalies of the kidney and urinary tract.

Authors:  Pedro Antunes Pousa; Tamires Sara Campos Mendonça; Larissa Marques Fonseca; Eduardo Araújo Oliveira; André Rolim Belisário; Ana Cristina Simões E Silva
Journal:  Mol Biol Rep       Date:  2022-02-25       Impact factor: 2.742
  1 in total

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