Peter Joslyn1, Cornelius Rosenbaum2, Andrew G Chapple2, Asha Heard3, Maria Velez4, Brian Barkemeyer5. 1. Department of Pediatrics Division of Neonatology, Louisiana State University Health Sciences Center New Orleans, New Orleans, LA, USA. pjosly@lsuhsc.edu. 2. Biostatistics Program, School of Public Health, Louisiana State University Health Sciences Center New Orleans, New Orleans, LA, USA. 3. Department of Obstetrics and Gynecology Division of Maternal Fetal Medicine, Louisiana State University Health Sciences Center New Orleans, New Orleans, LA, USA. 4. Department of Pediatrics Division of Hematology Oncology, Louisiana State University Health Sciences Center New Orleans, New Orleans, LA, USA. 5. Department of Pediatrics Division of Neonatology, Louisiana State University Health Sciences Center New Orleans, New Orleans, LA, USA.
Abstract
OBJECTIVE: To examine the relationship between maternal hypertension and early neonatal platelet counts. STUDY DESIGN: This single site retrospective cohort study compared initial platelet counts in the first day of life of infants born to mothers with preeclampsia with severe features (PSF) (n = 224) and infants born to normotensive mothers using multivariable logistic and Quasi-Poisson regression models. RESULT: There was no statistical difference in initial platelet counts or likelihood of thrombocytopenia (aOR = 1.19, 95% CI 0.68-2.08) between infants born to mothers with PSF and infants born to normotensive mothers after multivariable adjustment. Initial platelet counts and thrombocytopenia risk were unaffected by the presence of maternal end organ dysfunction. Small for gestational age (SGA) status was the most significant risk factor for the development of thrombocytopenia (aOR = 2.24, 95% CI 1.13-4.30). CONCLUSION: Maternal PSF does not directly affect neonatal initial platelet counts. SGA status confers the greatest risk of early thrombocytopenia.
OBJECTIVE: To examine the relationship between maternal hypertension and early neonatal platelet counts. STUDY DESIGN: This single site retrospective cohort study compared initial platelet counts in the first day of life of infants born to mothers with preeclampsia with severe features (PSF) (n = 224) and infants born to normotensive mothers using multivariable logistic and Quasi-Poisson regression models. RESULT: There was no statistical difference in initial platelet counts or likelihood of thrombocytopenia (aOR = 1.19, 95% CI 0.68-2.08) between infants born to mothers with PSF and infants born to normotensive mothers after multivariable adjustment. Initial platelet counts and thrombocytopenia risk were unaffected by the presence of maternal end organ dysfunction. Small for gestational age (SGA) status was the most significant risk factor for the development of thrombocytopenia (aOR = 2.24, 95% CI 1.13-4.30). CONCLUSION: Maternal PSF does not directly affect neonatal initial platelet counts. SGA status confers the greatest risk of early thrombocytopenia.