Literature DB >> 34845084

Crystal structure of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) frameshifting pseudoknot.

Christopher P Jones1, Adrian R Ferré-D'Amaré1.   

Abstract

SARS-CoV-2 produces two long viral protein precursors from one open reading frame using a highly conserved RNA pseudoknot that enhances programmed -1 ribosomal frameshifting. The 1.3 Å-resolution X-ray structure of the pseudoknot reveals three coaxially stacked helices buttressed by idiosyncratic base triples from loop residues. This structure represents a frameshift-stimulating state that must be deformed by the ribosome and exhibits base-triple-adjacent pockets that could be targeted by future small-molecule therapeutics. Published by Cold Spring Harbor Laboratory Press for the RNA Society.

Entities:  

Keywords:  COVID; RNA; X-ray; base triple; near-atomic resolution

Mesh：

Substances：

Year:  2021        PMID： 34845084      PMCID： PMC8906546          DOI： 10.1261/rna.078825.121

Source DB:  PubMed          Journal:  RNA        ISSN： 1355-8382            Impact factor:   4.942


  42 in total

1.  A simple and efficient method to reduce nontemplated nucleotide addition at the 3 terminus of RNAs transcribed by T7 RNA polymerase.

Authors:  C Kao; M Zheng; S Rüdisser
Journal:  RNA       Date:  1999-09       Impact factor: 4.942

2.  Coot: model-building tools for molecular graphics.

Authors:  Paul Emsley; Kevin Cowtan
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2004-11-26

3.  Crystal structure of a c-di-AMP riboswitch reveals an internally pseudo-dimeric RNA.

Authors:  Christopher P Jones; Adrian R Ferré-D'Amaré
Journal:  EMBO J       Date:  2014-09-30       Impact factor: 11.598

4.  Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome.

Authors:  Pramod R Bhatt; Alain Scaiola; Gary Loughran; Marc Leibundgut; Annika Kratzel; Romane Meurs; René Dreos; Kate M O'Connor; Angus McMillan; Jeffrey W Bode; Volker Thiel; David Gatfield; John F Atkins; Nenad Ban
Journal:  Science       Date:  2021-05-13       Impact factor: 63.714

5.  How good are my data and what is the resolution?

Authors:  Philip R Evans; Garib N Murshudov
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2013-06-13

6.  Overview of the CCP4 suite and current developments.

Authors:  Martyn D Winn; Charles C Ballard; Kevin D Cowtan; Eleanor J Dodson; Paul Emsley; Phil R Evans; Ronan M Keegan; Eugene B Krissinel; Andrew G W Leslie; Airlie McCoy; Stuart J McNicholas; Garib N Murshudov; Navraj S Pannu; Elizabeth A Potterton; Harold R Powell; Randy J Read; Alexei Vagin; Keith S Wilson
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2011-03-18

7.  Programmed ribosomal frameshifting in decoding the SARS-CoV genome.

Authors:  Pavel V Baranov; Clark M Henderson; Christine B Anderson; Raymond F Gesteland; John F Atkins; Michael T Howard
Journal:  Virology       Date:  2005-02-20       Impact factor: 3.616

8.  Comprehensive in vivo secondary structure of the SARS-CoV-2 genome reveals novel regulatory motifs and mechanisms.

Authors:  Nicholas C Huston; Han Wan; Madison S Strine; Rafael de Cesaris Araujo Tavares; Craig B Wilen; Anna Marie Pyle
Journal:  Mol Cell       Date:  2021-01-01       Impact factor: 17.970

9.  Secondary structure determination of conserved SARS-CoV-2 RNA elements by NMR spectroscopy.

Authors:  Anna Wacker; Julia E Weigand; Sabine R Akabayov; Nadide Altincekic; Jasleen Kaur Bains; Elnaz Banijamali; Oliver Binas; Jesus Castillo-Martinez; Erhan Cetiner; Betül Ceylan; Liang-Yuan Chiu; Jesse Davila-Calderon; Karthikeyan Dhamotharan; Elke Duchardt-Ferner; Jan Ferner; Lucio Frydman; Boris Fürtig; José Gallego; J Tassilo Grün; Carolin Hacker; Christina Haddad; Martin Hähnke; Martin Hengesbach; Fabian Hiller; Katharina F Hohmann; Daniel Hymon; Vanessa de Jesus; Henry Jonker; Heiko Keller; Bozana Knezic; Tom Landgraf; Frank Löhr; Le Luo; Klara R Mertinkus; Christina Muhs; Mihajlo Novakovic; Andreas Oxenfarth; Martina Palomino-Schätzlein; Katja Petzold; Stephen A Peter; Dennis J Pyper; Nusrat S Qureshi; Magdalena Riad; Christian Richter; Krishna Saxena; Tatjana Schamber; Tali Scherf; Judith Schlagnitweit; Andreas Schlundt; Robbin Schnieders; Harald Schwalbe; Alvaro Simba-Lahuasi; Sridhar Sreeramulu; Elke Stirnal; Alexey Sudakov; Jan-Niklas Tants; Blanton S Tolbert; Jennifer Vögele; Lena Weiß; Julia Wirmer-Bartoschek; Maria A Wirtz Martin; Jens Wöhnert; Heidi Zetzsche
Journal:  Nucleic Acids Res       Date:  2020-12-16       Impact factor: 16.971

10.  To Knot or Not to Knot: Multiple Conformations of the SARS-CoV-2 Frameshifting RNA Element.

Authors:  Tamar Schlick; Qiyao Zhu; Abhishek Dey; Swati Jain; Shuting Yan; Alain Laederach
Journal:  J Am Chem Soc       Date:  2021-07-20       Impact factor: 15.419
View more
  4 in total

1.  RT-qPCR as a screening platform for mutational and small molecule impacts on structural stability of RNA tertiary structures.

Authors:  Martina Zafferani; Dhanasheel Muralidharan; Nadeska I Montalvan; Amanda E Hargrove
Journal:  RSC Chem Biol       Date:  2022-06-06

Review 2.  Viral and cellular translation during SARS-CoV-2 infection.

Authors:  Gilbert Eriani; Franck Martin
Journal:  FEBS Open Bio       Date:  2022-04-25       Impact factor: 2.792

Review 3.  Translational Control of COVID-19 and Its Therapeutic Implication.

Authors:  Dejiu Zhang; Lei Zhu; Yin Wang; Peifeng Li; Yanyan Gao
Journal:  Front Immunol       Date:  2022-03-29       Impact factor: 7.561

4.  Length-dependent motions of SARS-CoV-2 frameshifting RNA pseudoknot and alternative conformations suggest avenues for frameshifting suppression.

Authors:  Shuting Yan; Qiyao Zhu; Swati Jain; Tamar Schlick
Journal:  Nat Commun       Date:  2022-07-25       Impact factor: 17.694
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.