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Literature DB >> 34843378

Drown Them in Their Own Garbage: a New Strategy To Reverse Polymyxin Resistance?

Abstract

Purcell and colleagues offer new insights into a major mechanism of polymyxin resistance in Gram-negative bacteria (A. B. Purcell, B. J. Voss, and M. S. Trent, J Bacteriol 204:e00498-21, 2022, https://doi.org/10.1128/JB.00498-21). Inactivating a single lipid recycling enzyme causes accumulation of waste lipid by-products that inhibit a key factor responsible for polymyxin resistance.

Entities: Chemical

Keywords: Gram-negative bacteria; antibiotic resistance; lipopolysaccharide; membranes; mobile colistin resistance; polymyxins

Mesh：

Substances：

Year: 2021 PMID： 34843378 PMCID： PMC8846470 DOI： 10.1128/JB.00574-21

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.476

Keyword Cloud
References

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